POT1 Antikörper (Middle Region)

Produktnummer ABIN785989

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch POT1 in WB. Es zeigt Reaktivität gegenüber Proben von Human, Ratte, Meerschweinchen, Hund und Pferd.

Kurzübersicht für POT1 Antikörper (Middle Region) (ABIN785989)

Target: POT1 (Protection of Telomeres 1 (POT1))

Reaktivität: Human, Ratte, Meerschweinchen, Hund, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser POT1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-POT1 Antikörper

Bindungsspezifität: Middle Region

Sequenz: CPKCHLLQEV PHEGDLDIIF QDGATKTPDV KLQNTSLYDS KIWTTKNQKG

Homologie: Dog: 79%, Guinea Pig: 85%, Horse: 79%, Human: 100%, Rat: 92%

Produktmerkmale: This is a rabbit polyclonal antibody against POT1. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human POT1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 634 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu POT1

Target: POT1 (Protection of Telomeres 1 (POT1))

Andere Bezeichnung: POT1

Hintergrund: This gene is a member of the telombin family and encodes a nuclear protein involved in telomere maintenance. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Increased transcriptional expression of this gene is associated with stomach carcinogenesis and its progression. Alternatively spliced transcript variants have been described.
Alias Symbols: DKFZP586D211, hPot1, HPOT1
Protein Interaction Partner: TPP1, CFL2, ACD, CORO1A, KHDRBS1, LAMC3, BCAS2, MVP, ZNF32, ECI1, CSNK2B, COX6A2, ALDH1A1, ACTN4, SERTAD1, C2orf74, ZBTB49, ZBED2, CYP4F11, MYO5C, RIF1, NAP1L1, MDM2, KRT18, GRN, PACSIN1, SULT4A1, PGLS, AIPL1, SH3BP1, HAAO, NCDN, TWF2, ACOT7, DDX19B, PACS
Protein Size: 634

Molekulargewicht: 71 kDa

Gen-ID: 25913

NCBI Accession: NM_001042594, NP_001036059

UniProt: Q9NUX5

Pathways: Zellzyklus, Telomere Maintenance