HIF1A Antikörper (N-Term)

Produktnummer ABIN784695

Zitiert in 1 Publikation. Der Kaninchen Polyklonal anti-HIF1A Antikörper (ABIN784695) detektiert spezifisch HIF1A in WB und IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus, Ratte, Rind (Kuh), Hund, Kaninchen, Ziege, Pferd, Zebrafisch (Danio rerio), Meerschweinchen und Saccharomyces cerevisiae.

Kurzübersicht für HIF1A Antikörper (N-Term) (ABIN784695)

Target: HIF1A (Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Kaninchen, Ziege, Pferd, Zebrafisch (Danio rerio), Meerschweinchen, Saccharomyces cerevisiae

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HIF1A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-HIF1A Antikörper

Bindungsspezifität: N-Term

Sequenz: EGAGGANDKK KISSERRKEK SRDAARSRRS KESEVFYELA HQLPLPHNVS

Homologie: Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 87%, Rabbit: 100%, Rat: 100%, Yeast: 100%, Zebrafish: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against HIF1A. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human HIF1A

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 735 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-HIF1A Antikörper (ABIN784695)

Li, Hu, Zhou, Zhou, Yang, Wang, Sun: "Hypoxia-inducible factor-1 alpha modulates muscle growth and the molting process through its regulation of glycolysis in Neocaridina davidi." in: The Journal of biological chemistry, Vol. 301, Issue 7, pp. 110298, (2025) (PubMed).

Details zu HIF1A

Target: HIF1A (Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A))

Andere Bezeichnung: HIF1A

Hintergrund: Hypoxia-inducible factor-1 (HIF1) is a transcription factor found in mammalian cells cultured under reduced oxygen tension that plays an essential role in cellular and systemic homeostatic responses to hypoxia. HIF1 is a heterodimer composed of an alpha subunit and a beta subunit. The beta subunit has been identified as the aryl hydrocarbon receptor nuclear translocator (ARNT). HIF1A is the alpha subunit of HIF-1. Overexpression of a natural antisense transcript (aHIF) of this gene has been shown to be associated with nonpapillary renal carcinomas. Two alternative transcripts encoding different isoforms have been identified.
Alias Symbols: HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78
Protein Interaction Partner: HDAC1, EP300, ARNTL, HDAC3, VHL, UBC, SUMO3, EGLN3, HIF1AN, SENP3, HSP90AA1, ATM, ARNT2, SART3, SUMO2, SIN3A, TRIM28, HSPA4, TRAF6, GNB2L1, EGLN1, SQSTM1, SUMO1, HEXIM1, LAMP2, HSPA8, RB1, SP1, SMAD3, MAFK, PCGF2, TCEB2, TCEB1, MAFG, HSP90AB1, DCUN1D1, RB
Protein Size: 735

Molekulargewicht: 83 kDa

Gen-ID: 3091

NCBI Accession: NM_181054, NP_851397

UniProt: Q16665

Pathways: Positive Regulation of Peptide Hormone Secretion, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Transition Metal Ion Homeostasis, Tube Formation, Regulation of Carbohydrate Metabolic Process, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals, Warburg Effekt