IL1R2 Antikörper (AA 301-398) (Cy3)

Produktnummer ABIN747761

Der Kaninchen Polyklonal anti-IL1R2 Antikörper wird verwendet zum Nachweis von IL1R2 in Proben von Human, Maus und Ratte. Er wurde validiert für WB, FACS, IF (cc) und IF (p).

Kurzübersicht für IL1R2 Antikörper (AA 301-398) (Cy3) (ABIN747761)

Target: IL1R2 (Interleukin 1 Receptor, Type II (IL1R2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IL1R2 Antikörper ist konjugiert mit Cy3

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-IL1R2 Antikörper (Cy3)

Bindungsspezifität: AA 301-398

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Dog

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human IL-1R II

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu IL1R2

Target: IL1R2 (Interleukin 1 Receptor, Type II (IL1R2))

Andere Bezeichnung: IL-1R2

Hintergrund:

Synonyms: IL1RB, CD121b, IL1R2c, CDw121b, IL-1R-2, IL-1RT2, IL-1RT-2, Interleukin-1 receptor type 2, CD121 antigen-like family member B, IL-1 type II receptor, Interleukin-1 receptor beta, IL-1R-beta, Interleukin-1 receptor type II, IL1R2

Background: Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity, this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.

Gen-ID: 7850

UniProt: P27930

Pathways: NF-kappaB Signalweg