Myeloid Differentiation Primary Response Gene (88) (MYD88) Antikörper (HRP)

Antigen: Myeloid Differentiation Primary Response Gene (88) (MYD88)

Synonyme: MYD88D, XMyD88, myd88d, MGC84928, DMMYD88, EP(2)2535, Kra, LD20892, MYD88, dMyD88, DmelCG2078, CG2078, zgc:103541, GB12344, NV10640, myd88, IRAK-2, MGC150550, AI649099, MGC102586, 6330415L08Rik, irak-2, MGC79591, IRAK2

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Maus, Ratte (Rattus), Human

Konjugat: HRP

Applikation: Western Blot (WB), ELISA

Produktnummer: ABIN736890

Produktbeschreibung

Weitere Bezeichnung: MyD88

Immunogen: Polyclonal antibodies are produced by immunizing animals with synthetic peptide derived from mouse MyD88

Format: Lyophilized

Wiederherstellung: Reconstitute with 100ul sterille distilled water. After reconstitution, stock concentration=1ug/1ul, preservatives included (BSA=10ug/ul, Sodium azide=0.1%)

Isotyp: IgG

Beschreibung: Synonym: myeloid differential protein-88, Myeloid differentiation primary response gene, MYD 88, MYD88D, Myeloid differentiation marker 88, Myeloid differentiation primary response gene 88, Myeloid differentiation primary response gene, Myeloid differentiation primary response protein MyD88.

Molekulargewicht: 34kDa

Kommentare:

The pro-inflammatory cytokine IL-1 induced cellular response requires IL-1 receptor complex including IL-1RI and IL-RAcP. Recently

MyD88 was identified as an adapter molecule in the IL-1 signaling pathway (Muzio et al. 1997). MyD88 associates with and recruits IRAK to the IL-1 receptor complex in response to IL-1 treatment and dominant negative form of MyD88 attenuates IL-1R mediated NF-kB activation. MyD88 is also employed as a regulator molecule by IL-18 receptor and human Toll receptor (Adachi et al. 1998

Medzhitov et al. 1998)

which are members in the Toll/IL-1R family of receptors. Targeted disruption of the MyD88 gene results in loss of cellular responses to IL-1 and IL-18

and MyD88-defecient mice lack responses to bacterial product LPS that employs Toll-like receptors 2 and 4 (TLR2 and TLR4) as the signaling receptors. MyD88 is a general adapter protein for the Toll/1R family of receptors and plays an important role in the inflammatory response induced by cytokines IL-1 and IL-18 and endotoxin. MyD88 gene is expressed in many tissues.

Synonyme: MYD88D, XMyD88, myd88d, MGC84928, DMMYD88, EP(2)2535, Kra, LD20892, MYD88, dMyD88, DmelCG2078, CG2078, zgc:103541, GB12344, NV10640, myd88, IRAK-2, MGC150550, AI649099, MGC102586, 6330415L08Rik, irak-2, MGC79591, IRAK2

Anwendungen

Applikationshinweise: WB (1:200-1000), ELISA (1:500-1000)

Konzentration: 1mg/1ml

Reinigung: Antibodies are purified by protein A and peptide affinity chromatography.

Buffer: 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

Lagerung: Ship at room temperature. Store at -20°C

Forschungsgebiet: Immunologie, Angeborene Immunität, Artherosklerose

Beschränkungen: Nur für Forschungszwecke einsetzbar