STAT3 Antikörper (pTyr705)

Produktnummer ABIN732638

Es sind 8+ Publikationen für dieses Produkt verfügbar. Der Kaninchen Polyklonal anti-STAT3 Antikörper wird verwendet zum Nachweis von STAT3 in Proben von Human, Maus, Ratte, Schwein, Kaninchen und Huhn. Er wurde validiert für WB, ELISA, IHC (p), FACS, IF (cc), IF (p) und IHC (fro).

Kurzübersicht für STAT3 Antikörper (pTyr705) (ABIN732638)

Target: STAT3 (Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3))

Reaktivität: Human, Maus, Ratte, Schwein, Kaninchen, Huhn

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser STAT3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-STAT3 Antikörper

Bindungsspezifität: pTyr705

Kreuzreaktivität: Huhn, Human, Maus, Schwein, Kaninchen, Ratte

Homologie: Dog,Cow,Sheep,Guinea Pig

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human STAT3 around the phosphorylation site of Tyr705

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-STAT3 Antikörper (ABIN732638)

Zhang, Zhang, Zuo, Wang, Zhang, Xu, Li, Chen: "JAK-STAT signaling regulation of chicken embryonic stem cell differentiation into male germ cells." in: In vitro cellular & developmental biology. Animal, Vol. 53, Issue 8, pp. 728-743, (2017) (PubMed).

Gao, Wang, Sun, Li, Wang, Yi, Wang: "Morusin shows potent antitumor activity for human hepatocellular carcinoma in vitro and in vivo through apoptosis induction and angiogenesis inhibition." in: Drug design, development and therapy, Vol. 11, pp. 1789-1802, (2017) (PubMed).

Badin, Sopariwala, Lorca, Narkar: "Muscle Arnt/Hif1β Is Dispensable in Myofiber Type Determination, Vascularization and Insulin Sensitivity." in: PLoS ONE, Vol. 11, Issue 12, pp. e0168457, (2017) (PubMed).

Lee, Lee, Kim, Kim, Yang, Jeong, Seong: "Radiation Inhibits Interleukin-12 Production via Inhibition of C-Rel through the Interleukin-6/ Signal Transducer and Activator of Transcription 3 Signaling Pathway in Dendritic Cells." in: PLoS ONE, Vol. 11, Issue 1, pp. e0146463, (2016) (PubMed).

Sur, Swier, Radwan, Agrawal: "Increased Expression of Phosphorylated Polo-Like Kinase 1 and Histone in Bypass Vein Graft and Coronary Arteries following Angioplasty." in: PLoS ONE, Vol. 11, Issue 1, pp. e0147937, (2016) (PubMed).

Iriyama, Hatta, Takei: "Direct effect of dasatinib on signal transduction pathways associated with a rapid mobilization of cytotoxic lymphocytes." in: Cancer medicine, Vol. 5, Issue 11, pp. 3223-3234, (2016) (PubMed).

Yang, Sun, Sun, Qi: "Effect of suppressor of cytokine signaling 2 (SOCS2) on fat metabolism induced by growth hormone (GH) in porcine primary adipocyte." in: Molecular biology reports, Vol. 39, Issue 9, pp. 9113-22, (2012) (PubMed).

Details zu STAT3

Target: STAT3 (Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3))

Andere Bezeichnung: STAT3

Hintergrund:

Synonyms: APRF, HIES, ADMIO, Signal transducer and activator of transcription 3, Acute-phase response factor, STAT3

Background: Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (By similarity).

Gen-ID: 6774

UniProt: P40763

Pathways: JAK-STAT Signalweg, RTK Signalweg, Interferon-gamma Pathway, Neurotrophin Signalübertragung, Dopaminergic Neurogenesis, Response to Growth Hormone Stimulus, Carbohydrate Homeostasis, Stem Cell Maintenance, Hepatitis C, Protein targeting to Nucleus, Feeding Behaviour, CXCR4-mediated Signaling Events, Signaling of Hepatocyte Growth Factor Receptor