Activating Transcription Factor 2 (ATF2) Antikörper

Antigen: Activating Transcription Factor 2 (ATF2)

Synonyme: HB16, CREB2, TREB7, CRE-BP1, MGC111558, ATF2, MGC142504, CHN1, CG12850, CG3749, dATF-2, DmelCG30420, CG30420

Wirt: Ziege

Produktnummer: ABIN645863

Produktbeschreibung

Produktmerkmale: Goat Anti-ATF2, with HRP-conjugated secondary antibody

Weitere Bezeichnung: ATF2

Swiss-Prot: NP_001871.2

Immunogen: Peptide with sequence C-IVMAPSSQSQPSGS, from the C Terminus of the protein sequence according to NP_001871.2, was used as an immunogen.

Kreuzreaktivität: Human, Maus, Ratte (Rattus), Affe

Wiederherstellung: Supplied as 100µg of purified antibody 0.5mg/ml in Tris saline, 0.02% sodium azide, pH 7.3 with 0.5% bovine serum albumin. Please avoid freeze-thaw cycles.

Isotyp: IgG  (Passende Sekundärantikörper)

Beschreibung: ATF2 (Activating Transcription Factor 2, CREBP, HB16, CREB2, TREB7) is a member of the ATF/CREB family of basic region leucine zipper DNA binding proteins that regulates transcription by binding to a consensus cAMP response element (CRE) in the promoter of various viral and cellular genes. Many of these genes are important in cell growth and differentiation, and in stress and immune responses. ATF2 is a nuclear protein that binds DNA as a dimer and can form dimers with members of the ATF/CREB and Jun/Fos families. It is a stronger activator as a heterodimer with cJun than as a homodimer. Several isoforms of ATF2 arise by differential splicing. The stable native full length ATF2 is transcriptionally inactive as a result of an inhibitory direct intramolecular interaction of its carboxy terminal DNA binding domain with the amino terminal transactivation domain. Following dimerization ATF2 becomes a short lived protein that undergoes ubiquitination and proteolysis, seemingly in a protein phosphatase-dependent mechanism. Stimulation of the transcriptional activity of ATF2 occurs following cellular stress induced by several genotoxic agents, inflammatory cytokines, and UV irradiation. This activation requires phosphorylation of two threonine residues in ATF2 by both JNK/SAP kinase and p38 MAP kinase. ATF2 is abundantly expressed in brain.

Spezifität: The Goat Anti-ATF2 antibody detects protein derived from human recombinant protein and HELA cell lysate at various concentrations.

Anwendungen

Bestandteile: HRP-conjugated secondary antibody provided along with this antibody

Lagerung: Store at -20 ° C, if not intended for use within a month, Keep it at 4 ° C and minimize freezing and thawing when use.

Forschungsgebiet: Immunologie, Angeborene Immunität, Transkriptionsfaktoren

Beschränkungen: Nur für Forschungszwecke einsetzbar