IL1R1 Antikörper (Extracellular Domain)

Produktnummer ABIN614470

Dieser Maus Monoklonal Antikörper detektiert spezifisch IL1R1 in IHC (p), IF, RIA und EIA. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für IL1R1 Antikörper (Extracellular Domain) (ABIN614470)

Target: IL1R1 (Interleukin 1 Receptor, Type I (IL1R1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser IL1R1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Radioimmunoassay (RIA), Enzyme Immunoassay (EIA)

Klon: 40101

Produktdetails anti-IL1R1 Antikörper

Bindungsspezifität: Extracellular Domain

Spezifität: These antibodies react with cell surface and soluble human IL-1 receptor. Specific epitopes are unknown, but they do partially inhibit (30-50 %) binding of one another to IL-1 receptor. They do not block binding of IL-1 to receptor, and they do not cross-react with receptors for Human IL-2 or IL-4.

Aufreinigung: Affinity chromatography on Protein G

Immunogen: Extracellular domain of the type I Human IL-1 receptor.

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1,0 mg/mL

Buffer: PBS, pH 7.4

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu IL1R1

Target: IL1R1 (Interleukin 1 Receptor, Type I (IL1R1))

Andere Bezeichnung: CD121a / IL1R1

Hintergrund: IL1R is a member of the interleukin 1 receptor family. An experiment with transient gene expression demonstrated that this receptor was incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affinity. IL1R is a receptor for interleukin 1 family member 9 (IL1F9). Binding to the agonist leads to the activation of NF-kappa-B. The gene for this protein and four other interleukin 1 receptor family genes, including interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 1 (IL1RL1), and interleukin 18 receptor 1 (IL18R1), form a cytokine receptor gene cluster in a region mapped to chromosome 2q12.Synonyms: IL-1R-alpha, IL1R, IL1RA, IL1RT1, Interleukin-1 receptor alpha, Interleukin-1 receptor type 1, Interleukin-1 receptor type I

Gen-ID: 3554

NCBI Accession: NP_000868

UniProt: P14778

Pathways: NF-kappaB Signalweg, Carbohydrate Homeostasis, Cancer Immune Checkpoints