XRCC4 Antikörper (Middle Region)

Produktnummer ABIN501232

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch XRCC4 in WB. Es zeigt Reaktivität gegenüber Proben von Human, Ratte, Maus, Rind (Kuh), Meerschweinchen, Pferd, Zebrafisch (Danio rerio), Hund, Kaninchen und Saccharomyces cerevisiae.

Kurzübersicht für XRCC4 Antikörper (Middle Region) (ABIN501232)

Target: XRCC4 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 4 (XRCC4))

Reaktivität: Human, Ratte, Maus, Rind (Kuh), Meerschweinchen, Pferd, Zebrafisch (Danio rerio), Hund, Kaninchen, Saccharomyces cerevisiae

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser XRCC4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-XRCC4 Antikörper

Bindungsspezifität: Middle Region

Sequenz: LQKENERLLR DWNDVQGRFE KCVSAKEALE TDLYKRFILV LNEKKTKIRS

Homologie: Cow: 100%, Dog: 93%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 92%, Rabbit: 92%, Rat: 92%, Yeast: 77%, Zebrafish: 85%

Produktmerkmale: This is a rabbit polyclonal antibody against XRCC4. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human XRCC4

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 336 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu XRCC4

Target: XRCC4 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 4 (XRCC4))

Andere Bezeichnung: XRCC4

Hintergrund: XRCC4 functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. The non-homologous end-joining pathway is required both for normal development and for suppression of tumors. This gene functionally complements XR-1 Chinese hamster ovary cell mutant, which is impaired in DNA double-strand breaks produced by ionizing radiation and restriction enzymes.The protein encoded by this gene functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. The non-homologous end-joining pathway is required both for normal development and for suppression of tumors. This gene functionally complements XR-1 Chinese hamster ovary cell mutant, which is impaired in DNA double-strand breaks produced by ionizing radiation and restriction enzymes. This gene contains 8 exons, and alternative transcription initiation and alternative splicing generates several transcript variants.
Alias Symbols: -
Protein Interaction Partner: BIN1, FAM9B, ASTE1, XRCC4, LIG4, PNKP, PRKDC, CSNK2A1, VPS41, NUDT21, CWC27, DENR, USP7, SRP54, DDX5, APTX, ERG, SUMO2, UBC, CALM1, XRCC5, XRCC6, SETMAR, AHNAK, CAAP1, IFFO1, APLF, CHD3, NHEJ1, VIM, GZMB, ACTN1, NBN,
Protein Size: 336

Molekulargewicht: 38 kDa

Gen-ID: 7518

NCBI Accession: NM_022406, NP_071801

UniProt: Q13426

Pathways: DNA Reparatur, Production of Molecular Mediator of Immune Response