Caspase 1 Antikörper (C-Term)

Produktnummer ABIN499541

Der Kaninchen Polyklonal anti-Caspase 1 Antikörper wird verwendet zum Nachweis von Caspase 1 in Proben von Human. Er wurde validiert für WB, IHC (p) und EIA.

Kurzübersicht für Caspase 1 Antikörper (C-Term) (ABIN499541)

Target: Caspase 1 (CASP1)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Caspase 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-Caspase 1 Antikörper

Bindungsspezifität: C-Term

Spezifität: Caspase-1 antibody was raised against a 16 amino acid peptide from near the carboxy-terminus of human Caspase-1.

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: Human Casp-1 / ICE / IL-1b converting enzyme (C-Terminus) Peptide

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western Blot: Casp-1 antibody can be used for the detection of Caspase-1 at 0.5 μg/mL. Immunohistochemistry: Casp-1 antibody can be used for the detection of Caspase-1 at 0.5 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu Caspase 1

Target: Caspase 1 (CASP1)

Andere Bezeichnung: Caspase-1

Hintergrund: Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens (reviewed in 1 and 2). Members of this subfamily include caspase-1, -4, -5, and -12 and can activate proinflammatory cytokines such as IL-1? and IL-18 (3,4). Caspase-1 was initially identified as an IL-1beta-converting enzyme (5), later experiments revealed it to be a mammalian homolog of the C. elegans cell death gene ced-3 (6) whose overexpression can induce apoptosis in fibroblasts (7).Synonyms: CASP-1, CASP1, ICE, IL1BC, IL1BCE, Interleukin-1 beta convertase, Interleukin-1 beta-converting enzyme, p45

Gen-ID: 834

NCBI Accession: NP_150634

UniProt: P29466

Pathways: Apoptose, Interferon-gamma Pathway, Positive Regulation of Endopeptidase Activity, Inflammasome