Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B) Antikörper

Antigen: Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B)

Synonyme: KIP1, MEN4, CDKN4, MEN1B, P27KIP1, p27, Rpn4, MGC8644, Kip1, Cdki1b, sb:cb611, wu:fb63g10, wu:fb64g10, wu:fe18e03, CDKN1B

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human

Applikation: Western Blot (WB)

Produktnummer: ABIN498272

Produktbeschreibung

Produktmerkmale: Synonyms: p27Kip1, Cyclin-dependent kinase inhibitor 1B, Cyclin-dependent kinase inhibitor p27

Weitere Bezeichnung: CDKN1B / KIP1

Gen-ID: 1027

Swiss-Prot: P46527

Kreuzreaktivität: Human

Beschreibung: Cell cycle progression is regulated by a series of cyclin-dependent kinases that consist ofcatalytic subunits, designated Cdks, and activating subunits designated cyclins. Orderlyprogression through the cell cycle requires the activation and inactivation of differentcyclin-Cdks at appropriate times. A series of proteins has been recently described thatfunction as “mitotic inhibitors. ” These include p21, the levels of which are elevated uponDNA damage in G1 in a p53-dependent manner, p16 and a more recently described p16related inhibitor designated p15. A p21 related protein, p27, has been described as anegative regulator of G1 progression and has been speculated to function as a possiblemediator of TGFβ-induced G1 arrest. p27 interacts strongly with D-type cyclins and Cdk4 invitro and to a lesser extent with cyclin E and Cdk2.

Spezifität: This antibody detects endogenous levels of p27 protein. Species Reactivity: Tested: Human

Anwendungen

Applikationshinweise: Western blot: 1: 500 - 1: 1000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Konzentration: 1.0 mg/ml

Reinigung: Aff - Purified

Buffer: Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2

Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer. Avoid repeatedfreezing and thawing. Shelf life: one year from despatch.

Forschungsgebiet: Krebs, Zellzyklus

Beschränkungen: Nur für Forschungszwecke einsetzbar