Cbl-Interacting Protein Sts-1 (STS1) (C-Term) Antikörper

Antigen: Cbl-Interacting Protein Sts-1 (STS1)

Synonyme: p70, STS1, STS-1, KIAA1959, MGC15437

Epitope: C-Term

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Hund

Applikation: Enzyme Immunoassay (EIA), Western Blot (WB)

Produktnummer: ABIN401302

Produktbeschreibung

Produktmerkmale: Synonyms: KIAA1959, STS-1, Ubiquitin-associated and SH3 domain-containing protein B, Suppressorof T-cell receptor signaling 1, Cbl-interacting protein p70

Weitere Bezeichnung: UBASH3B / STS1

Gen-ID: 84959

Swiss-Prot: Q8TF42

Immunogen: Synthetic peptide corresponding to the C-terminus of mouse Sts-1

Kreuzreaktivität: Hund, Human, Maus, Ratte (Rattus)

Isotyp: IgG  (Passende Sekundärantikörper)

Beschreibung: Sts-1 is a protein that inhibits endocytosis of epidermal growth factor receptor (EGFR) andplatelet-derived growth factor receptor. Sts-1 and Sts-2 (formerly p70 and Clip4,respectively) have been found to interact with Cbl, an ubiquitin ligase that plays a criticalrole in attenuation of receptor tyrosine kinase signaling by inducing ubiquitination andpromoting their sorting for endosomal degradation. Sts-1 and Sts-2 contain SH3 domainsthat interact with Cbl, Ub-associated domains, which bind directly to mono-Ub or to theEGFR/Ub chimera, as well as phosphoglycerate mutase domains that mediateoligomerization of Sts-1/2. Sts-1 and Sts-2 also have been found to negatively regulatesignaling pathways that control T cell receptors, which in turn affect the extent andduration of the T cell response to foreign pathogens.

Spezifität: This antibody is directed against Sts-1 protein. Species Reactivity: Tested: Mouse. Expected from sequence similarity: Rat, Human.

Anwendungen

Applikationshinweise: ELISA: 1/2,000 - 1/10,000. Western Blot: 1/500 - 1/3,000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Konzentration: 0.63 mg/ml (by UV absorbance at 280 nm)

Reinigung: Aff - Purified

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing0.01% (w/v) Sodium Azide

Lagerung: Store the antibody at -20°C. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Beschränkungen: Nur für Forschungszwecke einsetzbar