STAT3 Antikörper (pTyr705)

Produktnummer ABIN389665

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch STAT3 in WB. Es zeigt Reaktivität gegenüber Proben von Human. Es wurde in 6+ Publikationen zitiert.

Kurzübersicht für STAT3 Antikörper (pTyr705) (ABIN389665)

Target: STAT3 (Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser STAT3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB05666

Produktdetails anti-STAT3 Antikörper

Bindungsspezifität: pTyr705

Homologie: B, M, Pig, Rat

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This STAT3 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y705 of human STAT3.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-STAT3 Antikörper (ABIN389665)

Yu, Zhang, Zhang, Li: "SOCS3 overexpression inhibits advanced glycation end product-induced EMT in proximal tubule epithelial cells." in: Experimental and therapeutic medicine, Vol. 13, Issue 6, pp. 3109-3115, (2017) (PubMed).

Yan, Li, Li, DI, Shen, Zhang, Guo: "Expression of signal transducer and activator of transcription 3 and its phosphorylated form is significantly upregulated in patients with papillary thyroid cancer." in: Experimental and therapeutic medicine, Vol. 9, Issue 6, pp. 2195-2201, (2015) (PubMed).

Yin, Du, Cao, Liu, Xu, Xiang: "Reg3g Promotes Pancreatic Carcinogenesis in a Murine Model of Chronic Pancreatitis." in: Digestive diseases and sciences, (2015) (PubMed).

Zhao, Li, Liao, Luo, Shi, Feng, Chen: "Evodiamine Induces Apoptosis and Inhibits Migration of HCT-116 Human Colorectal Cancer Cells." in: International journal of molecular sciences, Vol. 16, Issue 11, pp. 27411-21, (2015) (PubMed).

Miyachi, Kobayashi, Relja, Fujita, Iwasa, Gabazza, Takei: "Effect of suppressor of cytokine signaling on hepcidin production in hepatitis C virus replicon cells." in: Hepatology research : the official journal of the Japan Society of Hepatology, Vol. 41, Issue 4, pp. 364-74, (2011) (PubMed).

Choi, Lee, Kwak, Kim, Lee, Ye, Kim, Kim, Lee: "Cooperation between integrin alpha5 and tetraspan TM4SF5 regulates VEGF-mediated angiogenic activity." in: Blood, Vol. 113, Issue 8, pp. 1845-55, (2009) (PubMed).

Details zu STAT3

Target: STAT3 (Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3))

Andere Bezeichnung: STAT3

Hintergrund: STAT3 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein.

Molekulargewicht: 88068

Gen-ID: 6774

NCBI Accession: NP_003141, NP_644805, NP_998827

UniProt: P40763

Pathways: JAK-STAT Signalweg, RTK Signalweg, Interferon-gamma Pathway, Neurotrophin Signalübertragung, Dopaminergic Neurogenesis, Response to Growth Hormone Stimulus, Carbohydrate Homeostasis, Stem Cell Maintenance, Hepatitis C, Protein targeting to Nucleus, Feeding Behaviour, CXCR4-mediated Signaling Events, Signaling of Hepatocyte Growth Factor Receptor