XRCC6 Antikörper (N-Term)

Produktnummer ABIN374763

Der Ziege Polyklonal anti-XRCC6 Antikörper (ABIN374763) detektiert spezifisch XRCC6 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für XRCC6 Antikörper (N-Term) (ABIN374763)

Target: XRCC6 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 6 (XRCC6))

Reaktivität: Human

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser XRCC6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-XRCC6 Antikörper

Bindungsspezifität: N-Term

Spezifität: This antibody reacts to KU70 / XRCC6.

Aufreinigung: Affinity chromatography

Immunogen: Peptide with sequence YKTEGDEEAEEEQ-C, from the N Terminus of the protein sequence

Anwendungsinformationen

Applikationshinweise: Peptide ELISA: 1/2000. Western Blot: 0.1 - 0.3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu XRCC6

Target: XRCC6 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 6 (XRCC6))

Andere Bezeichnung: XRCC6 / Ku70

Hintergrund: Ku70 heterodimerises with Ku80 to form the ATP-dependent DNA helicase II, a single stranded helicase that binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. The heterodimer plays a role in non-homologous end-joining (NHEJ) required for double-strand break repair and V(D)J recombination. It acts as the regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit (PRKDC) for DNA. The Ku70/80 heterodimer is also required for osteocalcin gene expression.Synonyms: 70 kDa subunit of Ku antigen, ATP-dependent DNA helicase 2 subunit 1, ATP-dependent DNA helicase II 70 kDa subunit, CTC box-binding factor 75 kDa subunit, CTC75, CTCBF, DNA repair protein XRCC6, G22P1, Lupus Ku autoantigen protein p70, TLAA, Thyroid-lupus autoantigen

Gen-ID: 2547, 9606

UniProt: P12956

Pathways: DNA Reparatur