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Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2) (AA 25-40) Antikörper

Antigen

Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2)
Synonyme HSD11B2, AME, AME1, HSD2, HSD11K, SDR9C3, MGC127544, MGC81883, 11-HSD2
Epitope

AA 25-40
Klonalität Polyklonal
Wirt
Alternativen

Kaninchen
Reaktivität
Alternativen

Human
Applikation
Alternativen Immunhistochemie (Paraffinschnitte) (IHC (p)), Western Blot (WB)
Produktnummer ABIN372479
Menge 50 µg  (1.0 mg/ml)
Preis 410,00 €   Zzgl. Versandkosten €20,00 und MWSt
Lieferung nach
Verfügbarkeit Lieferung in 7 bis 10 Werktagen

Produktbeschreibung
Anwendungen Alternativen Sekundärantikörper zurück nach oben

Produktmerkmale Synonyms: 11-beta-hydroxysteroid dehydrogenase 2, HSD11K, 11-DH2, Corticosteroid11-beta-dehydrogenase isozyme 2, NAD-dependent 11-beta-hydroxysteroid dehydrogenase
Weitere Bezeichnung 11-beta HSD2 / HSD11B2
Swiss-Prot P80365
Immunogen Synthetic peptide corresponding to amino acids 25-40 of human 11 beta-HSD2. AA Sequence: R25SDLRLGRPLLAALAL40
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Isotyp IgG  (Passende Sekundärantikörper)
Beschreibung HSD11B2 catalyzes the conversion of cortisol to the inactive metabolite cortisone. Theprotein modulates intracellular glucocorticoid levels, thus protecting the nonselectivemineralocorticoid receptor from occupation by glucocorticoids. Defects in HSD11B2 are the cause of apparent mineralocorticoid excess (AME). AME is apotentially fatal disease characterized by severe juvenile low-renin hypertension, sodiumretention, hypokalemia and low levels of aldosterone. It often leads to nephrocalcinosis.
Spezifität This antibody recognizes 11-HSD2. Species Reactivity: Tested: Human. Expected from sequence similarity: Mouse and Rat.

Anwendungen
Alternativen Sekundärantikörper zurück nach oben

Applikationshinweise Western blot: 1/200. Immunohistochemistry on Paraffin Sections: 10 µg/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Konzentration 1.0 mg/ml
Reinigung Aff - Purified
Buffer TBS, pH 7.4 containing 0.02% Sodium Azide as preservative and 0.5% BSA,50% Glycerol as stabilizers.
Lagerung Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Beschränkungen Nur für Forschungszwecke einsetzbar

Alternativen
Anwendungen Sekundärantikörper zurück nach oben

Alternativen zu Antigen "Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2)", Typ "Antikörper" finden
Wirte Kaninchen (6), Huhn (2), Maus (2)
Reaktivitäten Human (10), Ratte (Rattus) (4), Maus (3), Affe (2), Rind (Kuh) (1), Schwein (1), Kaninchen (1)
Applikationen Western Blot (WB) (9), ELISA (Detektionsantikörper) (4), Dot Blot (Dot) (1), Immunzytochemie (ICC) (1), Immunhistochemie (Gefrierschnitte) (IHC (fro)) (1), Immunpräzipitation (IP) (1)