Polo-Like Kinase Kinase (PLKK) (pSer482 486 490) Antikörper

Antigen: Polo-Like Kinase Kinase (PLKK)

Epitope: pSer482 486 490

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Xenopus laevis

Applikation: Western Blot (WB)

Produktnummer: ABIN361516

Produktbeschreibung

Weitere Bezeichnung: Phospho-Ser482,486,490 Polo-Like Kinase Kinase

Format: Affinity-purified

Beschreibung: Considerable evidence indicates that a polo-like kinase (PLK) plays an important role in cell cycle regulation. PLK is also required for bipolar spindle formation, activation of the anaphase-promoting complex/cyclosome, and cytokinesis. Recent work led to the identification of a PLKK that is thought to be responsible for activation of PLK. Recent work (Erikson, et al., 2004) has shown that PLKK is in turn activated by phosphorylation at three sites (Ser482, Ser486 and Ser490). Thus activation of PLK is thought to involve a kinase cascade involving the phosphorylation of Ser482,486,490 in PLKK.

Spezifität: Specific for the ~120k PLKK protein phosphorylated at Ser482,486,490.

Anwendungen

Applikationshinweise: Recommended Dilution: WB: 1:1000 Quality Control: Western blots performed on each lot.

Reinigung: Prepared from rabbit serum by affinity purification via sequential chromatography on phospho- and dephosphopeptide affinity columns.

Lagerung: Store at -20 °C, stable for 1 year

Beschränkungen: Nur für Forschungszwecke einsetzbar