Tyrosinase-Related Protein 1 Antikörper (4th Cytoplasmic Loop)

Produktnummer ABIN351091

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Tyrosinase-Related Protein 1 in IHC und WB. Er zeigt eine Reaktivität gegenüber Drosophila melanogaster.

Kurzübersicht für Tyrosinase-Related Protein 1 Antikörper (4th Cytoplasmic Loop) (ABIN351091)

Target: Tyrosinase-Related Protein 1 (TYRP1)

Reaktivität: Drosophila melanogaster

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Tyrosinase-Related Protein 1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Western Blotting (WB)

Produktdetails anti-Tyrosinase-Related Protein 1 Antikörper

Bindungsspezifität: 4th Cytoplasmic Loop

Verwendungszweck: Rabbit antibody to drosophila TRP

Spezifität: Specific for TRP.

Kreuzreaktivität: Drosophila melanogaster

Kreuzreaktivität (Details): Other species not yet tested.

Aufreinigung: IgG

Immunogen: A synthetic peptide from 4th cytoplasmic loop of drosophila TRP (Transient receptor potential protein) conjugated to an immunogenic carrier protein was used as the immunogen.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC WB. A concentration of 10-50,micro,g,ml is recommended. The optimal concentration should be determined by the end user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstitute in 500 µl of sterile water. Centrifuge to remove any insoluble material.

Handhabung: Avoid freeze and thaw cycles.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Haltbarkeit: 12 months

Details zu Tyrosinase-Related Protein 1

Target: Tyrosinase-Related Protein 1 (TYRP1)

Andere Bezeichnung: TRP

Hintergrund: FUNCTION: A light-sensitive calcium channel that is required for inositide-mediated Ca(2+) entry in the retina during phospholipase C (PLC)-mediated phototransduction. Ca(2+) influx may then feed back and inhibit PLC thereby facilitating phosphatidylinositol 4 5 bisphosphate (PIP2) recycling. Trp and trpl act together in the light response though it is unclear whether as heteromultimers or as distinct units and are activated by fatty acids and metabolic stress. Also required for olfactory adaptation and may be involved in olfactory system development. SUBUNIT: The C-terminus interacts with a PDZ domain of inaD to form the core of the inaD signaling complex. Other members of the complex include norpA (PLC) inaC (PKC) and possibly trpl ninaC FKBP59 calmodulin and rhodopsin. Forms homomultimers and heteromultimers with trpl. Interaction with trpl is mediated in part by the N-terminal region and the transmembrane domains. Also interacts though to a lower extent with trp-gamma. SUBCELLULAR LOCATION: Membrane, Multi-pass membrane protein. Note: Localized on plasma membrane loops found at the base of the rhabdomere in close proximity to the calcium stores. TISSUE SPECIFICITY: Expressed predominantly in the rhabdomeres of photoreceptor cells. Expressed in the third antennal segment and in the olfactory segment at approximately 70 hours after puparium formation during antennal development.

UniProt: P19334