LBP Antikörper

Produktnummer ABIN343174

Dieser Maus Monoklonal Antikörper detektiert spezifisch LBP in ELISA. Es zeigt Reaktivität gegenüber Proben von Maus. Es wurde in 3+ Publikationen zitiert.

Kurzübersicht für LBP Antikörper (ABIN343174)

Target: LBP (Lipopolysaccharide Binding Protein (LBP))

Reaktivität: Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser LBP Antikörper ist unkonjugiert

Applikation: ELISA

Klon: BiG35

Produktdetails anti-LBP Antikörper

Spezifität: Mouse LBP. The antibody don't blocks LPS binding to membrane bound CD14.

Kreuzreaktivität: Ratte (Rattus)

Aufreinigung: Protein A affinity column

Immunogen: native mouse LBP

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: ELISA, LBP inhibition studies, Western Blot. Non inhibition of LPS binding to membrane bound CD14, Binding titre at - ELISA: more than1:20.000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstitute with bidistilled water

Konzentration: 1 mg/mL

Buffer: PBS, pH 7.18

Konservierungsmittel: Without preservative

Lagerung: -20 °C,-80 °C

Referenzen für anti-LBP Antikörper (ABIN343174)

Stamme, Mueller, Hamann, Gutsmann, Seydel: "Surfactant protein a inhibits lipopolysaccharide-induced immune cell activation by preventing the interaction of lipopolysaccharide with lipopolysaccharide-binding protein." in: American journal of respiratory cell and molecular biology, Vol. 27, Issue 3, pp. 353-60, (2002) (PubMed).

Gutsmann, Mueller, Carroll, MacKenzie, Wiese, Seydel: "Dual role of lipopolysaccharide (LPS)-binding protein in neutralization of LPS and enhancement of LPS-induced activation of mononuclear cells." in: Infection and immunity, Vol. 69, Issue 11, pp. 6942-50, (2001) (PubMed).

Hamann, Schumann, Flad, Brade, Rietschel, Ulmer: "Binding of lipopolysaccharide (LPS) to CHO cells does not correlate with LPS-induced NF-kappaB activation." in: European journal of immunology, Vol. 30, Issue 1, pp. 211-6, (2000) (PubMed).

Details zu LBP

Target: LBP (Lipopolysaccharide Binding Protein (LBP))

Andere Bezeichnung: Lipopolysaccharide (LPS)-Binding Protein (LBP)

Hintergrund: Background: Natural Lipopolysccaride Binding Protein (LBP) is a 58KD glycoprotein produced in liver. It binds at lipid A of LPS with high affinity (10-9M) and reduced the cellular LPS effects at CD14+ cells (IL1ß, IL6, TNFα). It acts as opsonin for GRAM negative cells, LPS, neutrophiles and granulocytes.

Molekulargewicht: ~58kDa

Gen-ID: 16803

UniProt: Q61805

Pathways: TLR Signalweg, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Toll-Like Receptors Cascades, Monocarboxylic Acid Catabolic Process