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Activating Transcription Factor 2 (ATF2) Antikörper

Antigen

Activating Transcription Factor 2 (ATF2)

Synonyme HB16, CREB2, TREB7, CRE-BP1, MGC111558, ATF2, MGC142504, CHN1, CG12850, CG3749, dATF-2, DmelCG30420, CG30420
Klonalität Polyklonal
Wirt
Alternativen

Kaninchen

Reaktivität
Alternativen

Human

Applikation
Alternativen Enzyme Immunoassay (EIA), Immunpräzipitation (IP), Immunhistochemie (Paraffinschnitte) (IHC (p)), Western Blot (WB)
Produktnummer ABIN265321
Menge 100 µg  (1,0 mg/ml)  (Varianten)
Preis 320,00 €   Zzgl. Versandkosten €20,00 und MWSt
Lieferung nach
Verfügbarkeit Lieferung in 7 bis 10 Werktagen

Produktbeschreibung

Produktmerkmale Synonyms: ATF-2, CREB2, CREBP1, Activating transcription factor 2, CRE-BP1, HB16, CREB-2, CyclicAMP-dependent transcription factor ATF-2, cAMP-dependent transcription factor ATF-2,cAMP response element-binding protein CRE-BP1, Cyclic AMP-responsive element-bindingprotein 2
Weitere Bezeichnung ATF2
Swiss-Prot P15336
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Beschreibung The transcription factor ATF-2 (also called CRE-BP1) binds to both AP-1 and CRE DNAresponse elements and is a member of the ATF/CREB family of leucine zipper proteins. ATF-2 interacts with a variety of viral oncoproteins and cellular tumor suppressors and is atarget of the SAPK/JNK and p38 MAP kinase signaling pathways. Various forms of cellularstress, including genotoxic agents, inflammatory cytokines and UV irradiation, stimulatethe transcriptional activity of ATF-2. Cellular stress activates ATF-2 by phosphorylation ofThr69 and Thr71. Both SAPK and p38 MAPK have been shown to phosphorylate ATF-2 atthese sites in vitro and in cells transfected with ATF-2. Mutations of these sites result in theloss of stress-induced transcription by ATF-2. In addition, mutations at these sites reducethe ability of E1A and Rb to stimulate gene expression via ATF-2.
Spezifität ATF2 (D67/49) antibody detects endogenous levels of ATF2 protein. Species: Human, Mouse, Rat. Others not tested.

Anwendungen

Applikationshinweise ELISA: 1: 20000~1: 40000. WB: 1: 500~1: 1000. IHC: 1: 50~1: 200. IP: 1: 50~1: 200. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Konzentration 1,0 mg/ml
Reinigung Aff - Purified
Buffer Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Lagerung Store the antibody undiluted at 2-8°C. DO NOT FREEZE! Shelf life: one year from despatch.
Forschungsgebiet Immunologie, Angeborene Immunität, Transkriptionsfaktoren
Beschränkungen Nur für Forschungszwecke einsetzbar

Alternativen

Alternativen zu Antigen "Activating Transcription Factor 2 (ATF2)", Typ "Antikörper" finden
Wirte Kaninchen (163), Maus (17), Ziege (5), Schaf (5)
Reaktivitäten Human (186), Maus (110), Ratte (Rattus) (98), Hund (4), Rind (Kuh) (3), Schwein (2), Kaninchen (2), Huhn (1), Pferd (1)
Applikationen Western Blot (WB) (123), Immunhistochemie (IHC) (65), Immunhistochemie (Paraffinschnitte) (IHC (p)) (55), Immunfluoreszenz (IF) (53), Immunpräzipitation (IP) (38), Enzyme Immunoassay (EIA) (32), ELISA (24), Durchflusszytometrie (FACS) (19), Dot Blot (Dot) (9), Immunhistochemie (Gefrierschnitte) (IHC (fro)) (6), ELISA (Detektionsantikörper) (2), Immunhistochemie (formalinfixierte Schnitte) (IHC (f)) (2), Immunoelectron Microscopy (IEM) (1)
Konjugate Alexa Flour 488 (1), Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1), RBITC (1)
Epitope pThr69/51 (6), Ab-112 or 94 (5), Ab-62 or 44 (5), Ab-69 or 51 (5), Ab-71 or 53 (5), Ab-73 or 55 (5), pSer112 or 94 (5), pSer62 or 44 (5), pThr69 or 51 (5), pThr71 or 53 (5), pThr71/53 (5), pThr73 or 55 (5), pSer62/44 (4), pSer112/94 (3), pThr73/55 (3), S44 (2), S94 (2), S322 (1), pSer112, pSer94 (1), pSer340, pSer322 (1), pSer44 (1), pSer472 (1), pSer62, pSer44 (1), pSer94 (1), pThr51 (1), pThr69, pThr51 (1), pThr69/51 + pThr71/53 (1), pThr71 (1), pThr79, pThr51 (1)