Phospholipase C gamma 1 Antikörper

Produktnummer ABIN127317

Der Kaninchen Polyklonal anti-Phospholipase C gamma 1 Antikörper (ABIN127317) detektiert spezifisch Phospholipase C gamma 1 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Phospholipase C gamma 1 Antikörper (ABIN127317)

Target: Phospholipase C gamma 1 (PLCG1) (phospholipase C, gamma 1 (PLCG1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Phospholipase C gamma 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Phospholipase C gamma 1 Antikörper

Spezifität: The antibody recognizes 139 kDa human PLCγ 1&2.

Aufreinigung: Protein A affinity purified

Immunogen: Synthetic peptide surrounding amino acid 1252 of human PLCgamma2

Anwendungsinformationen

Applikationshinweise: Western Blot: 0.5-4 μg/mL, Jurkat cell lysate can be used as a positive control.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: PBS containing 30 % glycerol, 0.5 % BSA, and 0.01 % thimerosal

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C/-80 °C

Informationen zur Lagerung: Store the antibody undiluted at -20 °C or for long term storage (in aliquots) at -70 °C.

Details zu Phospholipase C gamma 1

Target: Phospholipase C gamma 1 (PLCG1) (phospholipase C, gamma 1 (PLCG1))

Andere Bezeichnung: PLCG1

Hintergrund: PLC (Phosphoinositide-specific phospholipase C) plays a significant role in transmembrane signaling. Four members of PLCs have been identified: PLCβ, PLCγ, PLCδ, and PLCε. In response to extracellular stimuli (e.g., hormone, growth factors, neurotransmitters), PLC hydrolizes phosphatidylinositol 4,5-biphosphate (PIP2) into two secondary messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). PLCγ2 is engaged in antigendependent signaling in B-cells and collagen-dependent signaling in platelets.Synonyms: 1-phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma-1, 5-bisphosphate phosphodiesterase gamma-2, PLC-148, PLC-II, PLC-IV, PLC-gamma-1, PLC-gamma-2, PLC1, PLCG-1, PLCG-2, PLCgamma2, Phospholipase C-gamma-1, Phospholipase C-gamma-2

Gen-ID: 5335

NCBI Accession: NP_877963

UniProt: P19174

Pathways: RTK Signalweg, WNT Signalweg, T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Thyroid Hormone Synthesis, Inositol Metabolic Process, Myometrial Relaxation and Contraction, Regulation of Muscle Cell Differentiation, Regulation of G-Protein Coupled Receptor Protein Signaling, Skeletal Muscle Fiber Development, G-protein mediated Events, Signaling Events mediated by VEGFR1 and VEGFR2, Interaction of EGFR with phospholipase C-gamma, VEGFR1 Specific Signals, VEGF Signaling