BRCA2 Antikörper (N-Term)

Produktnummer ABIN127309

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch BRCA2 in WB. Es zeigt Reaktivität gegenüber Proben von Human und Maus.

Kurzübersicht für BRCA2 Antikörper (N-Term) (ABIN127309)

Target: BRCA2 (Breast Cancer 2, Early Onset (BRCA2))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BRCA2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-BRCA2 Antikörper

Bindungsspezifität: N-Term

Spezifität: This antibody detects BRCA2.

Aufreinigung: Affinity Chromatography.

Immunogen: Synthetic peptide mapping to the N-terminus of Human BRCA2.

Anwendungsinformationen

Applikationshinweise: Western Blot: 0.5-4 μg/mL. HeLa cell lysate can be used as a Positive Control.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: PBS pH 7.2, containing 30 % Glycerol, 0.5 % BSA and 0.01 % Thimerosal

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C/-80 °C

Informationen zur Lagerung: Store the antibody undiluted at -20 °C or for long term storage (in aliquots) at -70 °C.

Details zu BRCA2

Target: BRCA2 (Breast Cancer 2, Early Onset (BRCA2))

Andere Bezeichnung: BRCA2 / FANCD1

Hintergrund: BRCA 1 and 2 are breast cancer susceptibility proteins that plays a role in DNA damage, repair, cell cycle progression, transcription and apoptosis, etc. The BRCA1 gene is expressed in numerous tissues, including breast and ovary, and encodes a predicted protein of 1863 amino acids. BRCA2 has been shown to be required for localization of Rad51 to sites of DSBs (double stranded breaks) in DNA. Cells lacking BRCA1 and BRCA2 cannot repair DSBs through the Rad51-dependent process.Synonyms: Breast cancer type 2 susceptibility protein, FACD, Fanconi anemia group D1 protein

Gen-ID: 675

NCBI Accession: NP_000050

UniProt: P51587

Pathways: DNA Reparatur, M Phase, Maintenance of Protein Location