STAT1 Antikörper (phosphorylated)

Produktnummer ABIN126895

Dieser Maus Monoklonal Antikörper detektiert spezifisch STAT1 in WB und EIA. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für STAT1 Antikörper (phosphorylated) (ABIN126895)

Target: STAT1 (Signal Transducer and Activator of Transcription 1, 91kDa (STAT1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser STAT1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Klon: 12C5

Produktdetails anti-STAT1 Antikörper

Bindungsspezifität: phosphorylated

Spezifität: This antibody specifically recognizes STAT1 phosphorylated at Ser 727. The antibody does not crossreact with the non-phosphorylated form of STAT1 nor with unrelated serine-phosphorylated proteins.

Produktmerkmale: Synonyms: STAT-1, STAT91, Signal transducer and activator of transcription 1-alpha/beta, Transcriptionfactor ISGF-3 components p91/p84

Aufreinigung: Size exclusion chromatography

Bestandteile: incl. positive Control

Immunogen: Synthetic phosphopeptide conjuagted to KLH

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Western Blot: 0.5 μg/mL for HRPO/ECL detection. Recommended blocking buffer: Casein/Tween 20 based blocking and blot incubationbuffer. ELISA: 0.05 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.1 mg/mL in in PBS/0.09 % Na-Azide/PEG and Sucrose/50 % Glycerol

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store the antibody (in alliquots) at -20 °C. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu STAT1

Target: STAT1 (Signal Transducer and Activator of Transcription 1, 91kDa (STAT1))

Andere Bezeichnung: STAT1

Hintergrund: The STAT proteins serve as both cytoplasmic signal transducers and nuclear activators of transcription. STATs are mediators involved in cytokine signalling. In response to a specific cytokine signal, STAT proteins are phosphorylated on conserved tyrosine residues. Phosphorylated STAT proteins dimerize via their SH2 domains and move to the nucleus. The STAT dimers bind to specific DNA elements resulting in transcriptional regulation of downstream target genes. STAT1 is activated by phosphorylation at serine 727. The phosphorylation state of Ser 727 regulates transcription and apoptosis. STAT1 can bind to DNA as heterodimer with STAT3.Synonyms: Signal transducer and activator of transcription 1-alpha/beta, Transcription factor ISGF-3 components p91/p84

UniProt: P42224

Pathways: JAK-STAT Signalweg, RTK Signalweg, Interferon-gamma Pathway, Response to Growth Hormone Stimulus, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Hepatitis C, CXCR4-mediated Signaling Events