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KLRK1 Antikörper (PE)

KLRK1 Reaktivität: Human FACS Wirt: Maus Monoclonal 1D11 PE
Produktnummer ABIN120295
  • Target Alle KLRK1 Antikörper anzeigen
    KLRK1 (Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1))
    Reaktivität
    • 58
    • 37
    • 8
    • 6
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 54
    • 21
    • 5
    • 5
    • 2
    • 1
    Maus
    Klonalität
    • 53
    • 33
    • 2
    Monoklonal
    Konjugat
    • 35
    • 10
    • 8
    • 6
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser KLRK1 Antikörper ist konjugiert mit PE
    Applikation
    • 52
    • 46
    • 16
    • 16
    • 15
    • 14
    • 13
    • 11
    • 7
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS)
    Spezifität
    This antibody is specific for CD314 also known as natural killer receptor G2 (NKG2D) and as killer cell lectin-like receptor subfamily K, member 1 (KLRK1). Clone 1D11 is reported to inhibit T cell recognition of MICA (1,6). We recommend the use of SM2260LE for such studies.
    Aufreinigung
    Affinity chromatography on Protein G
    Immunogen
    NKL cells. Spleen cells from immunised RBF/DnJ mice were fused with cells of the p3 mouse myeloma cell line.
    Klon
    1D11
    Isotyp
    IgG1
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  • Applikationshinweise
    Flow Cytometry (Neat-1/10): Use 10 μL of the suggested working dilution to label 106 cells in 100 μL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Rekonstitution
    Restore with 1.0 mL distilled water
    Buffer
    PBS, pH 7.4 containing 0.09 % Sodium Azide as preservative and 1 % BSA as stabilizer.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    This product is photosensitive and should be protected from light
    Lagerung
    4 °C
    Informationen zur Lagerung
    Prior to and following reconstitution store the antibody at 2-8 °C. DO NOT FREEZE!
  • Target
    KLRK1 (Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1))
    Andere Bezeichnung
    CD314 / KLRK1 (KLRK1 Produkte)
    Synonyme
    KLRK1 antikoerper, NKG2D antikoerper, CD314 antikoerper, D12S2489E antikoerper, KLR antikoerper, NKG2-D antikoerper, D6H12S2489E antikoerper, Nkg2d antikoerper, Nkrp2 antikoerper, killer cell lectin like receptor K1 antikoerper, killer cell lectin-like receptor subfamily K, member 1 antikoerper, NKG2D protein antikoerper, KLRK1 antikoerper, Klrk1 antikoerper, NKG2D antikoerper
    Hintergrund
    CD314 is a C-type lectin-like activating receptor which is expressed on most natural killer (NK) cells, CD8 T cells and gamma delta T cells. CD314 forms homodimers that signal through an associated DAP10 adaptor protein. Ligands of CD314 include MICA, MICB and UL16 binding protein (ULBP), which are inducibly expressed. Ligand binding to CD314 results in NK cell activation and potent costimulation of effector T cells.Synonyms: D12S2489E, Killer cell lectin-like receptor subfamily K member 1, NK cell receptor D, NKG2-D type II integral membrane protein, NKG2-D-activating NK receptor, NKG2D
    Gen-ID
    100528032
    NCBI Accession
    NP_001186734
    UniProt
    P26718
    Pathways
    Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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