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SH2D1A encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. Zusätzlich bieten wir Ihnen SH2 Domain Containing 1A Proteine (20) und SH2 Domain Containing 1A Kits (1) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 121 products:
Human Monoclonal SH2D1A Primary Antibody für ELISA, WB - ABIN561703
Ma, Suryani, Avery, Chan, Nanan, Santner-Nanan, Deenick, Tangye: Early commitment of naïve human CD4(+) T cells to the T follicular helper (T(FH)) cell lineage is induced by IL-12. in Immunology and cell biology 2009
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Human Polyclonal SH2D1A Primary Antibody für WB - ABIN1881802
Snow, Marsh, Krummey, Roehrs, Young, Zhang, van Hoff, Dhar, Nichols, Filipovich, Su, Bleesing, Lenardo: Restimulation-induced apoptosis of T cells is impaired in patients with X-linked lymphoproliferative disease caused by SAP deficiency. in The Journal of clinical investigation 2009
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Human Polyclonal SH2D1A Primary Antibody für WB - ABIN374582
Mikhalap, Shlapatska, Yurchenko, Yurchenko, Berdova, Nichols, Clark, Sidorenko: The adaptor protein SH2D1A regulates signaling through CD150 (SLAM) in B cells. in Blood 2004
Human Polyclonal SH2D1A Primary Antibody für WB - ABIN374629
Romero, Benítez, March, Vilella, Miralpeix, Engel: Differential expression of SAP and EAT-2-binding leukocyte cell-surface molecules CD84, CD150 (SLAM), CD229 (Ly9) and CD244 (2B4). in Tissue antigens 2004
Human Polyclonal SH2D1A Primary Antibody für IP, WB - ABIN265020
Sayos, Wu, Morra, Wang, Zhang, Allen, van Schaik, Notarangelo, Geha, Roncarolo, Oettgen, De Vries, Aversa, Terhorst: The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM. in Nature 1998
High LAT1 (zeige LAT Antikörper) expression correlated with significantly shorter prostate specific antigen (zeige KLK3 Antikörper) recurrence-free survival in patients receiving androgen deprivation therapy
We describe here a novel c.137+5G > A intronic mutation in the SH2D1A gene of the signaling lymphocyte activation molecule (SLAM (zeige SLAMF1 Antikörper))-associated protein (SAP) in association with Epstein-Barr virus (EBV)-induced fatal infectious mononucleosis (FIM (zeige ZMYM2 Antikörper)) in an 8-year-old male patient and his 3-year-old step brother. The mother and the maternal grandmother of the boys are healthy and heterozygous for this sequence variant.
In addition to their role in NK cell activation by hematopoietic cells, the SLAM-SAP-SHP1 pathways influence responsiveness toward nonhematopoietic targets by a process akin to NK cell 'education'.
The mutation c.131G>A in this patient was found in combination with a second SH2D1A mutation
Study of SAP (zeige APCS Antikörper) expression is specific but may have insufficient sensitivity for screening XLP1 as a single tool; however, combination with 2B4 (zeige CD244 Antikörper) functional assay allows identification of all cases
Molecular dynamics analysis revealed that mutant R32Q and T53I structures of SAP (zeige APCS Antikörper) exhibited structural variation with respect to their backbone atoms before and after binding with the unphosphorylated SLAM (zeige SLAMF1 Antikörper) peptide.
Signaling lymphocytic activation molecule (SLAM)/SLAM (zeige SLAMF1 Antikörper)-associated protein pathway regulates human B-cell tolerance.
In patients suffering from X-linked lymphoproliferative disease (XLP1), SAP (zeige APCS Antikörper) is nonfunctional, not only abolishing the activating function of 2B4 (zeige CD244 Antikörper), but rendering this receptor inhibitory.
our data reveal how SAP (zeige APCS Antikörper) nucleates a previously unknown signaling complex involving NTB-A (zeige SLAMF6 Antikörper) and LCK (zeige LCK Antikörper) to potentiate restimulation-induced cell death of activated human T cells.
SAP (zeige APCS Antikörper) is a new actor downstream of PECAM-1 (zeige PECAM1 Antikörper) and its binding regulates PECAM-1 (zeige PECAM1 Antikörper) mediated cell adhesion.
SAP (zeige APCS Antikörper) is an essential molecule for autoimmune antibody production.
SLAM (zeige SLAMF1 Antikörper)-SAP (zeige APCS Antikörper) signaling promotes differentiation of IL-17 (zeige IL17A Antikörper)-producing T cells and progression of experimental autoimmune encephalomyelitis.
these data suggest that SAP (zeige APCS Antikörper) is critical for regulating type II NKT (zeige CTSL1 Antikörper) cell responses.
functional analysis in vitro indicates that SAP-2 is a non-functional isoform due to decreased protein stability
Here we report that B cell intrinsic responses to haptenated protein antigens are impaired in SAP (zeige APCS Antikörper)-/- mice and in Rag-/- mice into which B cells derived from SAP (zeige APCS Antikörper)-/- mice together with wt CD4 (zeige CD4 Antikörper)+ T cells had been transferred.
SAP (zeige APCS Antikörper) plays an essential role in CIA (zeige NCOA5 Antikörper) because of Fyn (zeige FYN Antikörper)-independent and Fyn (zeige FYN Antikörper)-dependent effects on TFH cells and, possibly, other T cell types.
SAP (zeige APCS Antikörper) was required not only for the initiation but also for the progression of primary T cell-driven B cell responses to haptens.
Loss of SAP (zeige APCS Antikörper) expression is associated with invariant NKT (zeige CTSL1 Antikörper) cell cytotoxicity and defective lytic synapse formation.
SAP (zeige APCS Antikörper) is required for the development of innate phenotype in H2-M3--restricted Cd8 (zeige CD8A Antikörper)(+) T cells.
This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene.
Duncan disease SH2-protein
, SH2 domain-containing protein 1A
, SLAM associated protein/SH2 domain protein 1A
, SLAM-associated protein
, T cell signal transduction molecule SAP
, T-cell signal transduction molecule SAP
, signaling lymphocyte activation molecule-associated protein
, signaling lymphocytic activation molecule-associated protein
, SH2 domain protein 1A
, SH2 domain protein 1A, Duncan's disease (lymphoproliferative syndrome)
, Signaling lymphocytic activation molecule-associated protein
, Duncan disease homolog