anti-SMAD2 (SMAD2) Antikörper

Bezeichnung:: anti-SMAD, Mothers Against DPP Homolog 2 Antikörper (SMAD2)

Auf www.antikoerper-online.de finden Sie aktuell 490 SMAD, Mothers Against DPP Homolog 2 (SMAD2) Antikörper von 30 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen SMAD2 Kits (48) und SMAD2 Proteine (26) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 584 SMAD2 Produkte verfügbar.

Synonyme:: 7120426M23Rik, fj43c06, hMAD-2, hSMAD2, JV18, JV18-1, Madh2, Madr2, mMad2, Smad-2, wu:fj43c06, Xmad2, XSmad2

Alle Antikörper anzeigen	Gen	GeneID	UniProt
	SMAD2	4087	Q15796
	SMAD2	17126	Q62432
	SMAD2	29357	O70436
Alle Spezies anzeigen Weitere Synonyme anzeigen

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Am meisten referenzierte anti-SMAD2 Antikörper

Human Polyclonal SMAD2 Primary Antibody für WB - ABIN2801941 : Liu, Pouponnot, Massagué: Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes. in Genes & development 1998 (PubMed)
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Human Monoclonal SMAD2 Primary Antibody für ICC, FACS - ABIN969401 : Wendt, Smith, Schiemann: p130Cas is required for mammary tumor growth and transforming growth factor-beta-mediated metastasis through regulation of Smad2/3 activity. in The Journal of biological chemistry 2009 (PubMed)
Show all 2 Pubmed References
Human Monoclonal SMAD2 Primary Antibody für IF, IHC (p) - ABIN517619 : Talvinen, Tuikkala, Nykänen, Nieminen, Anttinen, Nevalainen, Hurme, Kuopio, Kronqvist: Altered expression of p120catenin predicts poor outcome in invasive breast cancer. in Journal of cancer research and clinical oncology 2010 (PubMed)
Human Polyclonal SMAD2 Primary Antibody für WB - ABIN362418 : Kim, Jong, Kim, Lee, Kim, Hong, Bang: Transforming growth factor-beta 1 induces apoptosis through Fas ligand-independent activation of the Fas death pathway in human gastric SNU-620 carcinoma cells. in Molecular biology of the cell 2004 (PubMed)
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Human Polyclonal SMAD2 Primary Antibody für WB - ABIN362416 : Zhang, Shen, Zhang, Wan, Yao, Wu, Wang, Chen, Yan, Jiang: Induction of thoracic aortic remodeling by endothelial-specific deletion of microRNA-21 in mice. in PLoS ONE 2013 (PubMed)
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Human Monoclonal SMAD2 Primary Antibody für FACS, IF - ABIN967045 : Hannan, Jamshidi, Pera, Wolvetang: BMP-11 and myostatin support undifferentiated growth of human embryonic stem cells in feeder-free cultures. in Cloning and stem cells 2009 (PubMed)
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Human Polyclonal SMAD2 Primary Antibody für WB - ABIN1842518 : Song, Thalacker, Nilsen-Hamilton: Synergistic and multidimensional regulation of plasminogen activator inhibitor type 1 expression by transforming growth factor type ? and epidermal growth factor. in The Journal of biological chemistry 2012 (PubMed)
Human Polyclonal SMAD2 Primary Antibody für ELISA, WB - ABIN257079 : Eppert, Scherer, Ozcelik, Pirone, Hoodless, Kim, Tsui, Bapat, Gallinger, Andrulis, Thomsen, Wrana, Attisano: MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma. in Cell 1996 (PubMed)
Human Polyclonal SMAD2 Primary Antibody für IHC (p), IHC - ABIN316295 : Lee, Lee, Bae, Jung: Abnormal liver differentiation and excessive angiogenesis in mice lacking Runx3. in Histochemistry and cell biology 2013 (PubMed)
Human Polyclonal SMAD2 Primary Antibody für ICC, IF - ABIN4354659 : Samanta, Gilkes, Chaturvedi, Xiang, Semenza: Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells. in Proceedings of the National Academy of Sciences of the United States of America 2014 (PubMed)

Weitere Antikörper gegen SMAD2 Interaktionspartner

Zebrafish SMAD, Mothers Against DPP Homolog 2 (SMAD2) Interaktionspartner

The non-Smad (zeige SMAD1 Antikörper) JNK (zeige MAPK8 Antikörper) signaling pathway, which is downstream of Nodal signaling, regulates nuclear movement independently of the Smad (zeige SMAD1 Antikörper) pathway, and this nuclear movement is associated with Smad (zeige SMAD1 Antikörper) signal transduction toward the nucleus.
The results of this study found that Bptf (zeige BPTF Antikörper) and TGF-beta (zeige TGFB1 Antikörper)/Smad2 mediate nucleosome remodeling to regulate wnt8a (zeige WNT8A Antikörper) expression and hence neural posteriorization.
Smad2 and Eomesodermin (zeige EOMES Antikörper) a (Eomesa (zeige EOMES Antikörper)) bind common genomic regions proximal to genes involved in mesoderm and endoderm formation, suggesting Eomesa (zeige EOMES Antikörper) forms a general component of the Smad2 signalling complex in zebrafish.
These results reveal that kinesin-mediated transport of Smad2 along microtubules to the receptors is an essential step in ligand-induced Smad2 activation.
study systemically uncovers a large number of Smad2 targets in early gastrulas and suggests cooperative roles of Smad2 and other transcription factors in controlling target gene transcription
Nodal signaling and mesendoderm induction depend on Smad2/3 and suggest that transforming growth factor-beta signals other than Nodal also contribute to Smad2/3 signaling and embryonic patterning.
Smad2/3 activities play important roles not only in mesendodermal development but also in neural development during early vertebrate embryogenesis

Human SMAD, Mothers Against DPP Homolog 2 (SMAD2) Interaktionspartner

High SMAD2 expression is associated with fibrosis in chronic pancreatitis and pancreatic cancer.
The results suggest that co-expression of active SMAD2/3 could enhance multiple types of transcription factors (TF)-based cell identity conversion and therefore be a powerful tool for cellular engineering.
We found that ITZ treatment was efficient in suppressing EMT (zeige ITK Antikörper) and that the effect of ITZ was partially mediated by impaired TGF-b/SMAD2/3 signaling. The role of TGF-b/SMAD2/3 signaling in mediating the effect of ITZ was confirmed based on the results that recombinant TGF-b induced, but the TGF-b neutralizing antibody inhibited EMT (zeige ITK Antikörper) as well as the invasion and migration of pancreatic cancer cells
SMAD2/3 interactome reveals that TGFbeta (zeige TGFB1 Antikörper) controls m(6)A mRNA methylation in pluripotency
This study's findings provide new insights into the mechanisms of how oscillatory shear stress regulates Smad2 signaling and pro-inflammatory genes through the complex signaling networks of integrins, transforming growth factor-beta receptors, and extracellular matrices, thus illustrating the molecular basis of regional pro-inflammatory activation within disturbed flow regions in the arterial tree.
our findings demonstrated that thymoquinone suppressed the metastatic phenotype and reversed EMT (zeige ITK Antikörper) of prostate cancer cells by negatively regulating the TGF-beta (zeige TGFB1 Antikörper)/Smad2/3 signaling pathway. These findings suggest that thymoquinone is a potential therapeutic agent against prostate cancer which functions by targeting TGF-beta (zeige TGFB1 Antikörper)
MicroRNA-486-5p suppresses TGFB2 (zeige TGFB2 Antikörper)-induced proliferation, invasion and epithelial-mesenchymal transition of lens epithelial cells by targeting Smad2.
was found that treatment with iPSC-CM markedly reduced the proliferation of TGF-beta1 (zeige TGFB1 Antikörper)-exposed cells, and the activities of TGF-beta1 (zeige TGFB1 Antikörper), Smad-2 and Smad-3 (zeige SMAD3 Antikörper). Accompanied by alterations in the expression of the indicated molecules, the lung structure of mice with PF was also markedly ameliorated.
We found expression of pSmad2/3 and Smad4 (zeige SMAD4 Antikörper) in different liver tissues, with up-regulated expression of both antibodies in chronic hepatitis C with higher stage of fibrosis and higher grade of activity.
TGFbeta (zeige TGFB1 Antikörper) and IL1beta (zeige IL1B Antikörper) signaling interact at the SMAD2/3 level in human primary MSC (zeige MSC Antikörper). Down-stream TGFbeta (zeige TGFB1 Antikörper) target genes were repressed by IL1beta (zeige IL1B Antikörper) independent of C-terminal SMAD2 phosphorylation. We demonstrate that SMAD2/3 linker modifications are required for this interplay and identified TAK1 (zeige MAP3K7 Antikörper) as a crucial mediator of IL1beta (zeige IL1B Antikörper)-induced TGFbeta (zeige TGFB1 Antikörper) signal modulation.

Xenopus laevis SMAD, Mothers Against DPP Homolog 2 (SMAD2) Interaktionspartner

Grg4 (zeige TLE4 Antikörper) occupancy at the Xnr1 (zeige NODAL Antikörper) enhancer significantly decreases with Smad2 overexpression.Nodal-activated Smad2 physically displaces Grg4 (zeige TLE4 Antikörper) from FoxH1 (zeige FOXH1 Antikörper) at the Xnr1 (zeige NODAL Antikörper) enhancer, an essential feature of the transcriptional switch mechanism.
E2a (zeige TCF3 Antikörper) is necessary to drive transcription of Smad2/3 target genes, including critical regulators of dorsal cell fate and morphogenesis
GDF11 (zeige GDF11 Antikörper) has a central role in the activation of Smad2 phosphorylation in tailbud stage Xenopus embryos.
XPIASy functions as an essential negative regulator of the XSmad2 pathway to ensure proper mesoderm induction at the appropriate time and in the appropriate region.

Pig (Porcine) SMAD, Mothers Against DPP Homolog 2 (SMAD2) Interaktionspartner

Activin A (zeige INHBA Antikörper) and overexpression of SMAD2/3 significantly promoted expressions of porcine NANOG (zeige NANOG Antikörper) and OCT4 (zeige POU5F1 Antikörper),maintaining induced pluripotent stem cell self-renewal through up-regulation of Nanog (zeige NANOG Antikörper)/OCT4 (zeige POU5F1 Antikörper) expression.

Cow (Bovine) SMAD, Mothers Against DPP Homolog 2 (SMAD2) Interaktionspartner

the present work provides evidence supporting a functional role of SMAD2/3 in bovine early embryogenesis
Mechanical compression not only with physiological but also with excessive stress can activate Smad2/3P signaling, which is known to be protective for articular cartilage and to block chondrocyte terminal differentiation.
a detailed computational model for TGF-beta (zeige TGFB1 Antikörper) signalling that incorporates elements of previous models together with crosstalking between Smad1 (zeige SMAD1 Antikörper)/5/8 and Smad2/3 channels through a negative feedback loop dependent on Smad7 (zeige SMAD7 Antikörper).

Mouse (Murine) SMAD, Mothers Against DPP Homolog 2 (SMAD2) Interaktionspartner

both ERK (zeige EPHB2 Antikörper) and Smad2 signal pathways are involved in the activation of macrophages induced by TGF-b1 and high-ambient glucose, while there is no crosstalk shown in the process.
Activin (zeige Actbeta Antikörper) signaling through SMAD2/3 in retinal progenitor cells regulates expression of transcription factors involved in cell type determination and promotes photoreceptor lineage specification.
Kidney samples from patients with advanced stages of diabetic nephropathy showed elevated pSmad2 staining whereas db/db (zeige LEPR Antikörper) mouse kidneys surprisingly showed a decrease in pSmad2 in the tubular compartment. These results indicate a lack of translation from type 2 diabetes patient kidneys to the db/db (zeige LEPR Antikörper) model with regards to Smad (zeige SMAD1 Antikörper) signaling pathway.
Results suggest that Smad2/3 linker threonine phosphorylation is expressed during acinar-ductal metaplasia.
NODAL/Activin (zeige Actbeta Antikörper) signaling induces dramatic chromatin landscape changes, and a dynamic transcriptional network regulated by SMAD2, acting via multiple mechanisms.
Blocking Smad2/3 signaling in pluripotent stem cells results in epigenetic changes that enhance the capacity for endoderm differentiation.
cells expressing mutant huntingtin (zeige HTT Antikörper) have a dysregulated transcriptional response to epidermal growth factor (zeige EGF Antikörper) stimulation
Smad2- and Smad3 (zeige SMAD3 Antikörper)-deficient bone marrow (BM) cells display reduced sensitivity to transforming growth factor-beta (TGFbeta (zeige TGFB1 Antikörper)) inhibition.
Data (including data from studies using knockout mice) suggest Garp/Lrrc32 (zeige LRRC32 Antikörper) is involved in up-regulation of Tgfb3 (zeige TGFB3 Antikörper) and is essential for embryogenesis of palate; Garp (zeige LRRC32 Antikörper) knockout causes postnatal lethality, cleft palate, and decreased apoptosis and Smad2 phosphorylation in medial edge epithelial cells of palatal shelf of embryos. (Garp (zeige LRRC32 Antikörper) = glycoprotein A repetitions predominant (zeige LRRC32 Antikörper) protein; Tgfb3 (zeige TGFB3 Antikörper) = transforming growth factor beta 3 (zeige TGFB3 Antikörper))
This study tested the hypothesis that inhibins act in an autocrine manner on Leydig cells using a pre-pubertal Leydig cell line, TM3 (zeige TPM1 Antikörper), as a model of immature Leydig cells.

SMAD2 Antigen-Profil

Beschreibung des Gens

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene.

Alternative names and synonyms associated with SMAD2

SMAD family member 2 (SMAD2) Antikörper
SMAD family member 2 (smad2) Antikörper
SMAD family member 2 S homeolog (smad2.S) Antikörper
SMAD family member 2-Z (SMAD2Z) Antikörper
SMAD family member 2 (Smad2) Antikörper

7120426M23Rik Antikörper
fj43c06 Antikörper
hMAD-2 Antikörper
hSMAD2 Antikörper
JV18 Antikörper
JV18-1 Antikörper
Madh2 Antikörper
Madr2 Antikörper
mMad2 Antikörper
Smad-2 Antikörper
wu:fj43c06 Antikörper
Xmad2 Antikörper
XSmad2 Antikörper

Bezeichner auf Proteinebene für SMAD2

SMAD, mothers against DPP homolog 2 , MAD (mothers against decapentaplegic, Drosophila) homolog 2 , SMA- and MAD-related protein 2 , SMAD 2 , SMAD family member 2 , mothers against DPP homolog 2 , mothers against decapentaplegic homolog 2 , MAD homolog 2 , Sma- and Mad-related protein 2 , mother against DPP homolog 2 , mothers against decapentaplegic-like 2 , Smad 2 , mad-related protein 2

GENE ID	SPEZIES
100033843	Equus caballus
496586	Xenopus (Silurana) tropicalis
30639	Danio rerio
4087	Homo sapiens
432023	Xenopus laevis
395247	Gallus gallus
480144	Canis lupus familiaris
100155304	Sus scrofa
516010	Bos taurus
17126	Mus musculus
29357	Rattus norvegicus
455407	Pan troglodytes

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