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SMAD2 Antikörper (AA 97-125)

SMAD2 Reaktivität: Human, Maus WB, ELISA, IF, FACS Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN3032613
  • Target Alle SMAD2 Antikörper anzeigen
    SMAD2 (SMAD, Mothers Against DPP Homolog 2 (SMAD2))
    Bindungsspezifität
    • 47
    • 37
    • 30
    • 26
    • 21
    • 16
    • 10
    • 9
    • 8
    • 8
    • 7
    • 6
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 97-125
    Reaktivität
    • 240
    • 152
    • 119
    • 12
    • 12
    • 9
    • 9
    • 8
    • 7
    • 7
    • 7
    • 6
    • 5
    • 4
    • 3
    • 3
    • 1
    • 1
    Human, Maus
    Wirt
    • 241
    • 12
    Kaninchen
    Klonalität
    • 215
    • 38
    Polyklonal
    Konjugat
    • 128
    • 18
    • 12
    • 10
    • 8
    • 8
    • 8
    • 8
    • 8
    • 7
    • 7
    • 5
    • 5
    • 5
    • 5
    • 5
    • 3
    • 3
    Dieser SMAD2 Antikörper ist unkonjugiert
    Applikation
    • 214
    • 103
    • 63
    • 53
    • 52
    • 45
    • 41
    • 41
    • 18
    • 14
    • 12
    • 11
    • 5
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS)
    Kreuzreaktivität (Details)
    Expected species reactivity: Rat, Bovine, Pig, Chicken, Zebrafish, Drosophila
    Aufreinigung
    Antigen affinity purified
    Immunogen
    A portion of amino acids 97-125 from the human protein was used as the immunogen for this SMAD2 antibody.
    Isotyp
    Ig Fraction
  • Applikationshinweise
    Titration of the SMAD2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Immunofluorescence: 1:100,Western blot: 1:1000,Flow Cytometry: 1:10-1:50
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    In 1X PBS, pH 7.4, with 0.09 % sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Aliquot the SMAD2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Target
    SMAD2 (SMAD, Mothers Against DPP Homolog 2 (SMAD2))
    Andere Bezeichnung
    SMAD2 (SMAD2 Produkte)
    Synonyme
    JV18 antikoerper, JV18-1 antikoerper, MADH2 antikoerper, MADR2 antikoerper, hMAD-2 antikoerper, hSMAD2 antikoerper, jv18 antikoerper, Xmad2 antikoerper, madh2 antikoerper, madr2 antikoerper, XSmad2 antikoerper, hmad-2 antikoerper, hsmad2 antikoerper, jv18-1 antikoerper, smad-2 antikoerper, fj43c06 antikoerper, wu:fj43c06 antikoerper, 7120426M23Rik antikoerper, Madh2 antikoerper, Madr2 antikoerper, Smad-2 antikoerper, mMad2 antikoerper, MAD homolog 2 antikoerper, Mothers against DPP homolog 2 antikoerper, SMAD 2 antikoerper, Smad2 antikoerper, SMAD family member 2 antikoerper, SMAD family member 2-Z antikoerper, SMAD family member 2 S homeolog antikoerper, SMAD2 antikoerper, SMAD2Z antikoerper, smad2 antikoerper, smad2.S antikoerper, Smad2 antikoerper
    Hintergrund
    Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. [UniProt]
    UniProt
    Q15796
    Pathways
    Zellzyklus, Hormone Transport, Chromatin Binding, Protein targeting to Nucleus
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