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These data reveal a MAPK pathway-independent switch in response to cAMP signaling during melanoma progression.Implications: The prosurvival mechanism involving the cAMP-EPAC-RAP1 signaling pathway suggest the potential for new targeted therapies in melanoma.
Rap1 telomeric and non-telomeric functions and potential implications in diabetic cardiomyopathy have been discussed. (Review)
the cytoplasmic RAP1-NF-kappaB-BCL2 axis represents a key pathway to cisplatin resistance in non-small cell lung cancer cells.
Rap1GAP functions as a novel suppressor of epithelial mesenchymal transformation and tumor metastasis in gastric cancer, and loss of Rap1GAP predicts poor prognosis.
The formation of the Rap1-TRF2 complex restored DNA unwinding.
Rap1 may induce hepatic ischemia reperfusion injury (IRI) through promoting neutrophils inflammatory response. Rap1 may be the potential therapeutic target of attenuating hepatic IRI.
The Rap1-RIAM-talin axis of integrin activation and blood cell function
Rap1 activation was dependent on PKA and required Src family kinases and the Rap1 exchanger C3G.
RAP1 promotes colorectal cell migration through the regulation of Vimentin and RAP1 may act as a potential target for the diagnosis and therapy of CRC.
Data show that isoform beta2 of the heregulin (HRGbeta2) localizes at telomeres with the telomere-associated proteins TRF2 and RAP1.
Data indicate telomere-binding protein RAP1 as an interacting partner of isoform beta2 of the heregulin (HRGbeta2).
In pro-inflammatory macrophages, Rap1 promotes cytokine production via NFkappaB activation favoring a pro-inflammatory environment which may contribute to the development and progression of atherosclerosis.
Through a combination of biochemical, biophysical and structural approaches, we unveiled a unique mode of assembly between RAP1 and TRF2
the conservation of Rap1 reflects its role in transcriptional regulation rather than a function at telomeres.
These findings reveal Pkp3 as a coordinator of desmosome and adherens junction assembly and maturation through its functional association with Rap1.
Data show that full-length repressor activator protein 1 (Rap1) binds to full-length telomeric repeat binding factor 2 (TRF2) with high affinity and equimolar ratio.
C3G/RAP1 activity is involved in the metastatic spread of epithelial ovarian cancer.
a detailed analysis of individual focal adhesion parameters identified focal adhesion size, sliding and intensity as primary targets of Rap1.
Nonsense mutations in the TERF2IP gene in familial melanoma: four families carried TERF2IP variants, which included nonsense mutations in both genes (p.Q320X and p.R364X, respectively).
results indicate that Rap1 miRNA can effectively enhance sensitivity of HepG2 cell line to 5-FU chemotherapy
The gene encodes a protein that is part of a complex involved in telomere length regulation. Pseudogenes are present on chromosomes 5 and 22.
, TERF2-interacting telomeric protein 1
, TRF2-interacting telomeric RAP1 protein
, TRF2-interacting telomeric protein 1
, dopamine receptor interacting protein 5
, dopamine receptor-interacting protein 5
, repressor/activator protein 1 homolog
, telomeric repeat-binding factor 2-interacting protein 1
, TRF2-interacting telomeric protein Rap1