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the 2.5A crystal structure of MPN (zeige PRSS27 Proteine) domain from Drosophila melanogaster CSN6.
Findings indicate that cops6 plays an anti-apoptotic role during segmentation.
CSN6 and Rab34 (zeige RAB34 Proteine) are involved in AR trafficking by regulating the phosphorylation signaling pathway. These findings provide new insights into the testosterone signaling pathway in Sertoli cells that mediates spermatogenesis.
results define a mechanism for the regulation of Myc (zeige MYC Proteine) stability through the CSN-Cullin-Fbxw7 (zeige FBXW7 Proteine) axis and provide insights into the correlation of CSN6 overexpression with Myc (zeige MYC Proteine) stabilization/activation during tumorigenesis
loss of CSN6 enhances p53 (zeige TP53 Proteine)-mediated tumor suppression in vivo and CSN6 plays an important role in regulating DNA damage-associated apoptosis and tumorigenesis through control of the MDM2 (zeige MDM2 Proteine)-p53 (zeige TP53 Proteine) signaling pathway
High CSN6 expression is associated with metastasis of glioblastoma.
The overexpression of CSN6 reduced the effect of quercetin treatment on HT29 cells, suggesting that quercetininduced apoptosis may involve the AktCSN6Myc signaling axis in HT29 cells.
CSN6 positively regulates c-Jun (zeige JUN Proteine) in a MEKK1 (zeige MAP3K1 Proteine)-dependent manner
our results indicate that CSN6 is a positive regulator of E6AP (zeige ube3a Proteine) and is important for cervical cancer development.
CSN6 interacts with p27(Kip1 (zeige CDKN1B Proteine)) and facilitates ubiquitin-mediated degradation of p27(Kip1 (zeige CDKN1B Proteine)).
Findings indicate that the deregulation of beta-catenin (zeige CTNNB1 Proteine) by extracellular signal-regulated kinase 2 (ERK2 (zeige MAPK1 Proteine))-activated CSN6 protein is important for colorectal cancer (CRC (zeige CALR Proteine)) development.
Analyses of the pseudo metal-binding motif in CSN6 suggest that the loss of two key histidine residues may contribute to the lack of catalytic activity in CSN6.
Data suggest that CSN6 is an important negative regulator of p57 (Kip2 (zeige CDKN1C Proteine)) , and that overexpression of CSN6 in many types of cancer could lead to decreased expression of p57 (Kip2 (zeige CDKN1C Proteine)) and result in promoted cancer cell growth.
COPS6 is a target gene of the BACH1 (zeige BACH1 Proteine) transcription factor according to ChIP-seq analysis in HEK (zeige EPHA3 Proteine) 293 cells.
The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein belongs to translation initiation factor 3 (eIF3) superfamily. It is involved in the regulation of cell cycle and likely to be a cellular cofactor for HIV-1 accessory gene product Vpr.
COP9 (constitutive photomorphogenic) homolog, subunit 6
, COP9 constitutive photomorphogenic homolog subunit 6
, COP9 signalosome complex subunit 6
, drosophila COP9 signalosome homolog 6
, COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis)
, COP9 (constitutive photomorphogenic), subunit 6
, COP9 complex S6
, JAB1-containing signalosome subunit 6
, signalosome subunit 6
, COP9 signalosome subunit 6
, COP9 subunit 6 (MOV34 homolog, 34 kD)
, MOV34 homolog, 34 kD
, vpr-interacting protein