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anti-Human CDK3 Antikörper:
anti-Mouse (Murine) CDK3 Antikörper:
anti-Rat (Rattus) CDK3 Antikörper:
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ectopic expression of HuR (zeige ELAVL1 Antikörper) promotes breast cancer cell proliferation and survival by directly binding to and stabilizing CDK3 mRNA.
These results provided evidence supporting the oncogenic potential of NFAT3 (zeige NFATC4 Antikörper) and suggested that CDK3-mediated phosphorylation of NFAT3 (zeige NFATC4 Antikörper) has an important role in skin tumorigenesis.
The analysis of tumor and matched normal lung tissues indicates that miR (zeige MLXIP Antikörper)-150 downregulation in lung tumors correlates with higher CDK3 levels. In addition, miR (zeige MLXIP Antikörper)-150 transfection experiments with cancer-derived cell lines reveal that miR (zeige MLXIP Antikörper)-150-mediated CDK3 suppression directly induces growth inhibition.
High Cdk3-promoted epithelial-mesenchymal transition through activating AP-1 (zeige FOSB Antikörper) is involved in colorectal cancer metastasis.
Data indicate that microRNA miR (zeige MLXIP Antikörper)-214 has tumor-suppressive activity in hepatocellular carcinoma (HCC (zeige FAM126A Antikörper)) through inhibition of E2F2 transcription factor (E2F2 (zeige E2F2 Antikörper)), cyclin (zeige PCNA Antikörper)-dependent kinases CDK3 and CDK6 (zeige CDK6 Antikörper).
Mir (zeige MLXIP Antikörper)-873 inhibits ESR1 (zeige ESR1 Antikörper) activity and cell growth via targeting CDK3.
CDK3 is associated with the progression of NPC (zeige NPC1 Antikörper), and may be a potential biomarker for prediction of the prognosis of patients with NPC (zeige NPC1 Antikörper).
The Walleye dermal sarcoma virus cyclin (zeige PCNA Antikörper) functions as a structural ortholog of cyclin C (zeige CCNC Antikörper) in spite of its limited amino acid sequence identity with C cyclins or with any known cyclins and activates Cdk8 (zeige CDK8 Antikörper) and Cdk3.
A non-cdk8 (zeige CDK8 Antikörper)-associated cellular pool of cyclin C (zeige CCNC Antikörper) combines with cdk3 to stimulate pRb (zeige RB1 Antikörper) phosphorylation at S807/811 during the G0/G1 transition, and this phosphorylation is required for cells to exit G0 efficiently.
Expression level of cdk3 is higher in human cancer cell lines and glioblastoma tissue compared with normal brain tissue. cdk3 phosphorylates activating transcription factor 1 (ATF1 (zeige AFT1 Antikörper))and enhances the transactivation and transcriptional activities of ATF1 (zeige AFT1 Antikörper).
Results indicated that CDKL3 (zeige CDKL3 Antikörper) may be involved in proliferation of cells surrounding the brain ventricle where neuronal progenitor cells are enriched during the late embryo st
CDKL3 (zeige CDKL3 Antikörper) is involved in neuronal morphogenesis during development.
This gene encodes a member of the cyclin-dependent protein kinase family. The protein promotes entry into S phase, in part by activating members of the E2F family of transcription factors. The protein also associates with cyclin C and phosphorylates the retinoblastoma 1 protein to promote exit from G0.
cell division protein kinase 3 , cyclin-dependent kinase 3