CDK3 Antikörper (C-Term)

Produktnummer ABIN6260712

Produktdetails anti-CDK3 Antikörper

Target: CDK3 (Cyclin-Dependent Kinase 3 (CDK3))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CDK3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Spezifität: CDK3 Antibody detects endogenous levels of total CDK3.

Homologie: Pig,Bovine,Sheep,Rabbit

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human CDK3, corresponding to a region within C-terminal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000-3000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Referenzen für anti-CDK3 Antikörper (ABIN6260712)

Wang, Xi, Sun, Zhang, Jiang, He, Li: "CDK3 is a major target of miR-150 in cell proliferation and anti-cancer effect." in: Experimental and molecular pathology, Vol. 102, Issue 2, pp. 181-190, (2017) (PubMed).

Details zu CDK3

Target: CDK3 (Cyclin-Dependent Kinase 3 (CDK3))

Andere Bezeichnung: CDK3 (CDK3 Produkte)

Synonyme: 2310050O10Rik antikoerper, Cdk3 antikoerper, cyclin dependent kinase 3 antikoerper, cyclin-dependent kinase 3 antikoerper, cyclin-dependent kinase 3, pseudogene antikoerper, CDK3 antikoerper, cgd3_1510 antikoerper, Chro.30182 antikoerper, Cdk3-ps antikoerper

Hintergrund:

Description: Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle, involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1-independent manner.

Gene: CDK3

Molekulargewicht: 35 kDa

Gen-ID: 1018

UniProt: Q00526

Pathways: Zellzyklus