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anti-Human BTRC Antikörper:
anti-Rat (Rattus) BTRC Antikörper:
anti-Mouse (Murine) BTRC Antikörper:
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Strong ERK (zeige MAPK1 Antikörper) activation can target Cdc25A (zeige CDC25A Antikörper) for degradation in a manner similar to, but independent of, Chk1 (zeige CHEK1 Antikörper) for cell cycle arrest.
SCFbeta-TRCP negatively regulates the FLCN (zeige FLCN Antikörper) complex by promoting FNIP2 (zeige FNIP2 Antikörper) degradation in Birt-Hogg-Dube syndrome-associated renal cancer.
beta-TRCP depletion in HepG2 hepatocellular carcinoma cells resulted in increased Lipin1 protein abundance.
It demonstrates that degradation of Lipin-1 (zeige LPIN1 Antikörper) is regulated by BTRC in the cytoplasm and on membranes
we identified two independent SNPs (i.e., WNT2B (zeige WNT2B Antikörper) rs1175649 G>T and BTRC rs61873997 G>A) that showed a predictive role in CM-specific survival, with an effect-allele-attributed hazards ratio (adjusted hazards ratio) of 1.99 (95% confidence interval = 1.41-2.81, P = 8.10 x 10(-5)) and 0.61 (0.46-0.80, 3.12x10(-4)), respectively.
It has been proposed that CENP-W (zeige CENPW Antikörper) may function as a booster of beta-TrCP1 nuclear import to increase the oncogenicity of beta-TrCP1.
oncogenic effect of miR (zeige MLXIP Antikörper)-182 and its reversal by beta-TrCP2 were confirmed in vivo This study suggests that beta-TrCP and miR (zeige MLXIP Antikörper)-182 may be possible biomarkers and targets for early detection and treatment of pancreatic cancer
Beta-TrCP controls ubiquitination and degradation of liver-enriched transcription factor CREB-H (zeige CREB3L3 Antikörper).
Phosphorylated VEGFR-2 (zeige KDR Antikörper) was reduced by hyperglycemia while total VEGFR-2 (zeige KDR Antikörper) was almost unaltered. However, VEGFR-2 (zeige KDR Antikörper) was reduced when directly exposed to reactive oxygen species, with resultant co-location of beta-TrCP and VEGFR-2 (zeige KDR Antikörper).
Low GAS7C increases cancer cell motility by promoting N-WASP/FAK (zeige PTK2 Antikörper)/F-actin cytoskeleton dynamics. It also enhances beta-catenin (zeige CTNNB1 Antikörper) stability via hnRNP U (zeige HNRNPU Antikörper)/beta-TrCP complex formation.
EBV-miR (zeige MLXIP Antikörper)-BART10-3p facilitated epithelial-mesenchymal transition and promotes metastasis of nasopharyngeal carcinoma by targeting BTRC.
beta-TrCP regulates the transition from mitosis to meiosis in male germ cells by targeting DMRT1 (zeige DMRT1 Antikörper) for degradation.
Data indicate a critical physiological function of beta-TRCP in regulating hepatic lipid metabolic homeostasis in part through modulating Lipin1 (zeige LPIN1 Antikörper) stability.
betaTrCP levels are correlated with imiquimod-induced skin lesion.
beta-TrCP1/FWD1 dominant negative mutant has a role in reducing myeloma cell growth
Erbin (zeige ERBB2IP Antikörper) as a novel substrate of SAG (zeige RNF7 Antikörper)-betaTrCP E3 ligase.
these results clearly suggest that both beta-TrCP- and Hrd1 (zeige SYVN1 Antikörper)-dependent degradation mechanisms regulate the transcriptional activity of Nrf1 (zeige NRF1 Antikörper) to maintain cellular homeostasis.
beta-TrCP may be an essential player in UVB induced responses in skin
Glycogen synthase kinase 3 (zeige GSK3a Antikörper) phosphorylates a group of Ser (zeige SIGLEC1 Antikörper) residues in the Neh6 domain of mouse Nrf2 (zeige NFE2L2 Antikörper) that overlap with an SCF (zeige KITLG Antikörper)/beta-TrCP destruction motif (DSGIS, residues 334 to 338) and promotes its degradation in a Keap1 (zeige KEAP1 Antikörper)-independent manner.
LPS (zeige TLR4 Antikörper) appears to destabilize the LPCAT1 (zeige LPCAT1 Antikörper) protein by GSK-3beta-mediated phosphorylation within a canonical phosphodegron for beta-TrCP docking and site-specific ubiquitination.
the two beta-TrCP paralogs have a nonredundant role in spermatogenesis
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class\; in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6.
beta-transducin repeat containing
, beta-transducin repeat containing protein
, F-box/WD repeat-containing protein 1A
, f-box/WD repeat-containing protein 1A-like
, F-box and WD repeats protein beta-TrCP
, F-box and WD-repeat protein 1B
, epididymis tissue protein Li 2a
, pIkappaBalpha-E3 receptor subunit
, beta-transducin repeat-containing protein
, SCF b-TRCP
, beta-TrCP protein E3RS-IkappaB
, pIkappaB-E3 receptor subunit
, ubiquitin ligase FWD1