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Disrupting the spindle assembly checkpoint in the aurA mutant does not prevent neuroblast amplification, tumor formation or chromosome segregation.
Aurora A kinase activity contributes to phosphorylation of kinetochore substrates near poles and its inhibition results in chromosome misalignment and an increased incidence of erroneous kinetochore-MT attachments.
AurA and aPKC exert the spatiotemporal control of Lgl distribution to achieve unique cell polarity roles in distinct cell types.
Aurora A and B kinases directly phosphorylate Lgl to promote its mitotic relocalization.
Drosophila melanogaster aurora A phosphorylates the dynactin (zeige DCTN1 ELISA Kits) subunit p150(glued (zeige DCTN1 ELISA Kits)) on sites required for its association with the mitotic spindle.
One of the functions of Aurora A kinase is to direct centrosomal organization such that D-TACC complexed to the MSPS/XMAP215 (zeige CKAP5 ELISA Kits) microtubule-associated protein (zeige FAM82A2 ELISA Kits) may be recruited, and thus modulate the behavior of astral microtubules.
Drosophila Aurora-A is required for centrosome maturation and actin-dependent asymmetric protein localization during mitosis.
Deletion mapping identifies a central domain of Aurora-A as essential for its centrosomal localization that is augmented by both the amino and the carboxyl terminal ends of the protein.
Results suggest that Aurora-A regulates centrosome assembly by controlling centrosomin's (CNN) ability to target and/or anchor gamma-tubulin (zeige TUBG1 ELISA Kits) to the centrosome and to organize microtubule-nucleating sites via interaction with CNN.
Aurora-A is essential for many crucial events during mitosis and phosphorylation of a series of substrates by Aurora-A at different stages of mitosis may promote diverse critical events in mitosis to maintain chromosome integrity in cells
Zebrafish Aurora-A is critically required for embryonic proliferation during development.
Although research biopsies were obtained on only a few patients, they did confirm pharmacodynamic effects of the drug. These effects though suggest inhibition of Aurora B (zeige AURKB ELISA Kits) rather than Aurora A, which consistent with pre-clinical data that show dose-dependent effects on both
Aurora A kinase is hyperphosphorylated in early mitosis under oxidative stress, which may disturb the function of Aurora A in mitotic spindle formation.
Our findings suggested that AURKA (rs911160) and AURKB (zeige AURKB ELISA Kits) (rs2289590) polymorphisms could affect GC risk. Further validation studies in larger and multi-ethnical populations are needed to elucidate their functional impact on the development of GC
Possible models of regulation of Lck (zeige LCK ELISA Kits) by Aurora-A during T cell activation are described in the review.
our study demonstrate that KCTD12 (zeige KCTD12 ELISA Kits) binds to CDC25B (zeige CDC25B ELISA Kits) and activates CDK1 (zeige CDK1 ELISA Kits) and Aurora A to facilitate the G2/M transition and promote tumorigenesis and that Aurora A phosphorylates KCTD12 (zeige KCTD12 ELISA Kits) at serine 243 to trigger a positive feedback loop, thereby potentiating the effects of KCTD12 (zeige KCTD12 ELISA Kits). Thus, the KCTD12 (zeige KCTD12 ELISA Kits)-CDC25B (zeige CDC25B ELISA Kits)-CDK1 (zeige CDK1 ELISA Kits)-Aurora A axis has important implications for cancer diagnoses and prognoses.
Our findings showed novel regulatory mechanisms of p53 (zeige TP53 ELISA Kits) in regulating Aurora-A gene expression in non-small cell lung carcinoma cells.
HIP2 (zeige UBE2K ELISA Kits) regulates mitotic spindle alignment. SHIP2 (zeige INPPL1 ELISA Kits) is expressed in G1 phase, whereas Aurora A kinase is enriched in mitosis. SHIP2 (zeige INPPL1 ELISA Kits) binds Aurora A kinase and the scaffolding protein HEF1 (zeige NEDD9 ELISA Kits) and promotes their basolateral localization at the expense of their luminal expression connected with cilia resorption.
Aurora kinase inhibitor CCT137690 induces necrosis-like death in pancreatic ductal adenocarcinoma cells, via RIPK1, RIPK3, and MLKL signaling.
our data indicate that hnRNP (zeige HNRNPC ELISA Kits) Q1 is a novel trans-acting factor that binds to Aurora-A mRNA 5'-UTRs and regulates its translation, which increases cell proliferation and contributes to tumorigenesis in colorectal cancer
A central role of Aurora kinase A (AURKA) in promoting Epithelial-to-mesenchymal transition and cancer stem cell phenotypes via ALDH1A1 (zeige ALDH1A1 ELISA Kits).
Aurora A and Plk4 (zeige PLK4 ELISA Kits) are rate-limiting factors contributing to microtubule growth as the acentriolar oocyte resumes meiosis.
The high sequence similarity among the AURK family members has made discerning the individual kinase functions in meiosis challenging. Technical limitations in specifically targeting AURKB (zeige AURKB ELISA Kits) or AURKC (zeige AURKC ELISA Kits) using small-molecule inhibitors and compensatory abilities in single-knockout animals add to this challenge...proper regulation of AURKA expression is crucial for spindle formation in meiosis
CIP2A (zeige KIAA1524 ELISA Kits) acts as a scaffold for CEP192-mediated microtubule organizing center assembly by recruiting Plk1 (zeige PLK1 ELISA Kits) and aurora A during meiotic maturation in mouse oocytes
AURKA stabilizes MYC (zeige MYC ELISA Kits) to promote tp53 (zeige TP53 ELISA Kits)-altered liver tumor cell survival.
Bcl2l10 (zeige BCL2L10 ELISA Kits), Tpx2 (zeige DAZL ELISA Kits), and Aurka co-localized on the meiotic spindles, and Bcl2l10 (zeige BCL2L10 ELISA Kits) was present in the same complex with Tpx2 (zeige DAZL ELISA Kits).
Suppression of neuroendocrine and NEPC development by ICT was associated with dose-dependent inhibitory effects on abnormally elevated IL-6 (zeige IL6 ELISA Kits)/STAT3 (zeige STAT3 ELISA Kits) and Aurora kinase A in vitro and in vivo
Our findings demonstrate that prolonged overexpression of Aurora-A can be a driver somatic genetic event in mammary adenocarcinomas associated with deregulated tumor-relevant pathways in the Aurora-A subset of human breast cancer
Data show that aurora-A kinase (AURKA) supports effective spindle formation in zygote.
observations revealed that the alteration of PKB-GSK-3beta axis, Plk-1, and Aurora kinase-A expressions in HSPC compartment due to DNA damage response was associated with the proliferative impairment and apoptosis during aplastic anemia.
Aurora A was the most abundant form in oocytes, both at mRNA and protein levels, in bovine oocytes during meiotic maturation.
Aurora kinase A is unlikely to be involved in CPEB1 (zeige CPEB1 ELISA Kits) activating phosphorylation and cyclin B1 (zeige CCNB1 ELISA Kits) mRNA polyadenylation during meiotic maturation of porcine oocytes.
Aurora-A may be a multifunctional kinase that plays pivotal regulatory roles in microtubule assembly during porcine oocyte meiotic maturation, fertilization and early embryonic mitosis
Aurora A stimulates the protein synthesis and promotes the meiotic resumption.
These results suggest a novel relationship between AurA and protein phosphatases during progression throughout the early embryonic cell cycle and shed new light on potential defects caused by AurA overexpression.
MCAK (zeige KIF2C ELISA Kits) colocalized with NuMA (zeige NUMA1 ELISA Kits) and XMAP215 (zeige CKAP5 ELISA Kits) at the center of Ran asters where its activity is regulated by Aurora A-dependent phosphorylation of S196, which contributes to proper pole focusing
Plx1 (zeige PLK1 ELISA Kits) promotes activation of Aurora A, most likely through TPX2.
Aurora-A kinase is required for astral microtubule polymerization and spindle microtubule flux during chromosome segregation.
Data show that Aurora A is a key regulator of microtubule assembly during M phase and therefore of bipolar spindle formation.
binding and elution properties of both the phosphopeptides and unphosphorylated peptides of His6-Aurora A
Results suggest that phosphorylation of maskin (zeige TACC3 ELISA Kits) by Aurora-A prevents meiosis II proteins from being produced during meiosis I.
The N-terminal non-catalytic domain of Aurora-A can localize to the centrosome in Xenopus egg extracts, while GFP fusions of either the N-terminal or catalytic domains are targeted to the centrosome in Xenopus XL2 cells.
Here we identify G205 in Xenopus Aurora A as a key determinant of both intrinsic activity and regulation by TPX2
The catalytic domain alone of Aurora-A is sufficient to restore spindle bipolarity; additional N-terminal sequences function in mitotic timing.
The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene.
A-type aurora kinase
, aurora A
, aurora A kinase
, aurora kinase
, Aurora A
, hypothetical protein
, aurora kinase A
, serine/threonine-protein kinase 6
, serine/threonine protein kinase 6
, aurora A kinase protein
, serine/threonine-protein kinase 6-like
, Aurora-A kinase
, IPL1-related kinase
, aurora 2
, aurora-related kinase 1
, aurora/IPL1-like kinase
, aurora/IPL1-related kinase 1
, breast tumor-amplified kinase
, breast-tumor-amplified kinase
, protein phosphatase 1, regulatory subunit 47
, serine/threonine kinase 6
, serine/threonine protein kinase 15
, serine/threonine-protein kinase 15
, serine/threonine-protein kinase aurora-A
, aurora family kinase 1
, ipl1- and aurora-related kinase 1
, serine/threonine-protein kinase Ayk1
, Serine/threonine-protein kinase 6
, aurora kinase A-A
, serine/threonine-protein kinase 6-A
, serine/threonine-protein kinase Eg2
, serine/threonine-protein kinase Eg2-A