WRAP53 Produkte
(WD Repeat Containing, Antisense To TP53 (WRAP53))
Kategorien
This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene. [provided by RefSeq, Mar 2011].
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Ausgewählte WRAP53 Kategorien
WRAP53 Antikörper
High quality antibodies with extensive validation data.
WRAP53 ELISA Kits
Reliable ELISA kits for a wide range of species.
WRAP53 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene WRAP53 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IF
Validierungen
- (1)
- (4)
Kat. Nr.
ABIN527367
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IF
Validierungen
- (1)
- (3)
Kat. Nr.
ABIN527366
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB
Validierungen
- (1)
- (1)
Kat. Nr.
ABIN527365
Menge
50 μg
Datenblatt
Datenblatt
Empfohlene WRAP53 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Validierungen
Kat. Nr.
ABIN1161126
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Mouse
Analytical Method
Validierungen
Kat. Nr.
ABIN1161127
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Rat
Analytical Method
Validierungen
Kat. Nr.
ABIN1161128
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene WRAP53 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
HEK-293 Cells
Validierungen
- (3)
Kat. Nr.
ABIN7556030
Menge
1 mg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1325280
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
Kat. Nr.
ABIN7580287
Menge
100 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren WRAP53 Produkten
: "N-terminal residues of human dyskerin are required for interactions with telomerase RNA that prevent RNA degradation." in: Nucleic acids research, Vol. 47, Issue 10, pp. 5368-5380, (2019) (PubMed).: "Clinical, cellular, and bioinformatic analyses reveal involvement of WRAP53 overexpression in carcinogenesis of lung adenocarcinoma." in: Tumour biology, Vol. 39, Issue 3, pp. 1010428317694309, (2017) (PubMed).
: "Minimized human telomerase maintains telomeres and resolves endogenous roles of H/ACA proteins, TCAB1, and Cajal bodies." in: eLife, Vol. 5, (2016) (PubMed).
: "Dynamics of Human Telomerase Holoenzyme Assembly and Subunit Exchange across the Cell Cycle." in: The Journal of biological chemistry, Vol. 290, Issue 35, pp. 21320-35, (2015) (PubMed).
: "Human regulator of telomere elongation helicase 1 (RTEL1) is required for the nuclear and cytoplasmic trafficking of pre-U2 RNA." in: Nucleic acids research, Vol. 43, Issue 3, pp. 1834-47, (2015) (PubMed).
: "Downregulation of the cancer susceptibility protein WRAP53β in epithelial ovarian cancer leads to defective DNA repair and poor clinical outcome." in: Cell death & disease, Vol. 6, pp. e1892, (2015) (PubMed).
: "The scaffold protein WRAP53? orchestrates the ubiquitin response critical for DNA double-strand break repair." in: Genes & development, Vol. 28, Issue 24, pp. 2726-38, (2014) (PubMed).
: "TCAB1: a potential target for diagnosis and therapy of head and neck carcinomas." in: Molecular cancer, Vol. 13, pp. 180, (2014) (PubMed).
: "Telomerase recruitment requires both TCAB1 and Cajal bodies independently." in: Molecular and cellular biology, Vol. 32, Issue 13, pp. 2384-95, (2012) (PubMed).
: "WRAP53 promotes cancer cell survival and is a potential target for cancer therapy." in: Cell death & disease, Vol. 2, pp. e114, (2011) (PubMed).
Synonyme und alternative Namen zu WRAP53
WD repeat containing antisense to TP53 (WRAP53), WD repeat containing, antisense to TP53 (Wrap53), WD repeat containing, antisense to Trp53 (Wrap53), BC021790, DKCB3, TCAB1, WDR79, Wdr79Bezeichner auf Proteinebene für WRAP53
- WD repeat-containing protein 79
- WD40 protein Wrap53
- WD40 repeat-containing protein encoding RNA antisense to p53
- telomerase Cajal body protein 1
- WD repeat domain 79
- WD40 repeat-containing protein encoded by RNA antisense to p53
- WD repeat containing, antisense to TP53
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