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Tcf7l1 defines the border between the neural crest and the prospective forebrain via restriction of the Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signaling gradient.
report the identification of two independent missense variants in human TCF7L1, p.R92P and p.R400Q, in a cohort of patients with forebrain and/or pituitary defects
The authors find that downstream of glycogen synthase kinase 3 (zeige GSK3a Proteine) inhibition, elevated cMyc (zeige MYC Proteine) and beta-catenin (zeige CTNNB1 Proteine) act in parallel to reduce transcription and DNA binding, respectively, of the transcriptional repressor Tcf7l1.
Sox4 and Tcf7l1 form a functional axis that promotes the progression of BCR-ABL (zeige ABL1 Proteine)-positive acute lymphoblastic leukemia.
The role of Tcf7l1 in mammals is to inhibit the gene regulatory network to ensure the coordination of lineage specification with the dynamic cellular events occurring during gastrulation.
results establish TCF7L1 as a transcriptional hub coordinating cell-cell contact with the transcriptional repression required for adipogenic competency
Tcf3-/- embryos proceed through gastrulation to form mesoderm, but they develop expanded and often duplicated axial mesoderm structures, including nodes and notochords.
E2A (zeige TCF3 Proteine)-PBX1 (zeige PBX1 Proteine) interacts directly with the KIX domain of CBP/p300 (zeige CREBBP Proteine) in the induction of proliferation in primary hematopoietic cells
Tcf3-mediated control of Nanog levels allows stem cells to balance the creation of lineage-committed and undifferentiated cells
These data suggest that in the absence of Wnt (zeige WNT2 Proteine) signals, Tcf3 may function in skin SCs (zeige TWIST1 Proteine) to maintain an undifferentiated state and, through Wnt (zeige WNT2 Proteine) signaling, directs these cells along the hair lineage.
HIPK2 (zeige HIPK2 Proteine) up-regulates transcription by phosphorylating TCF3 (zeige TCF3 Proteine), a transcriptional repressor, but inhibits transcription by phosphorylating LEF1 (zeige LEF1 Proteine), a transcriptional activator.
Tcf3is partially responsible for the butyrate-resistant phenotype of colorectal cancer cells, as this DNA-binding protein (zeige UBE2V1 Proteine) suppresses the hyperinduction of Wnt (zeige WNT2 Proteine) activity by butyrate.
Our results identify TCF3 (zeige TCF3 Proteine) as a central regulator of tumor growth and initiation.
TCF3 (zeige TCF3 Proteine), a novel positive regulator of osteogenesis, plays a crucial role in miR-17 modulating the diverse effect of canonical Wnt (zeige WNT2 Proteine) signaling in different microenvironments.
TCF (zeige HNF4A Proteine)/TLE tetramer complex promotes structural transitions of chromatin to mediate repression.
These results indicate that a dynamic interplay of TCF (zeige HNF4A Proteine) transcription factors governs MYC (zeige MYC Proteine) gene expression in colorectal cancers.
TCF7L1 (zeige TCF3 Proteine), a Wnt (zeige WNT2 Proteine) pathway repressor, buffers CTNNB1 (zeige CTNNB1 Proteine)/TCF (zeige HNF4A Proteine) target gene expression to promote CRC (zeige CALR Proteine) growth
TCF7L1 (zeige TCF3 Proteine) plays a major role in maintaining hESC pluripotency, which has implications for human development during gastrulation
Through transcriptome profiling and combined gain- and loss-of-function studies, the authors identified LCN2 (zeige LCN2 Proteine) as a major downstream effector of TCF7L1 (zeige TCF3 Proteine) that drives tumor growth.
report the identification of two independent missense variants in human TCF7L1 (zeige TCF3 Proteine), p.R92P and p.R400Q, in a cohort of patients with forebrain and/or pituitary defects
This gene encodes a member of the T cell factor/lymphoid enhancer factor family of transcription factors. These transcription factors are activated by beta catenin, mediate the Wnt signaling pathway and are antagonized by the transforming growth factor beta signaling pathway. The encoded protein contains a high mobility group-box DNA binding domain and participates in the regulation of cell cycle genes and cellular senescence.
HMG box transcription factor 3
, T-cell factor 3
, transcription factor 3
, transcription factor 7-like 1
, transcription factor 7-like 1 (T-cell specific, HMG box)
, transcription factor 7-like 2 (T-cell specific, HMG box)
, HMG box transcription factor 3-A
, transcription factor 7-like 1-A
, transcription factor XTCF-3b