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HIPK2 up-regulates transcription by phosphorylating TCF3, a transcriptional repressor, but inhibits transcription by phosphorylating LEF1, a transcriptional activator.
Tcf3is partially responsible for the butyrate-resistant phenotype of colorectal cancer cells, as this DNA-binding protein suppresses the hyperinduction of Wnt activity by butyrate.
Our results identify TCF3 as a central regulator of tumor growth and initiation.
TCF3, a novel positive regulator of osteogenesis, plays a crucial role in miR-17 modulating the diverse effect of canonical Wnt signaling in different microenvironments.
TCF/TLE tetramer complex promotes structural transitions of chromatin to mediate repression.
These results indicate that a dynamic interplay of TCF transcription factors governs MYC gene expression in colorectal cancers.
TCF7L1, a Wnt pathway repressor, buffers CTNNB1/TCF target gene expression to promote CRC growth
TCF7L1 plays a major role in maintaining hESC pluripotency, which has implications for human development during gastrulation
Through transcriptome profiling and combined gain- and loss-of-function studies, the authors identified LCN2 as a major downstream effector of TCF7L1 that drives tumor growth.
report the identification of two independent missense variants in human TCF7L1, p.R92P and p.R400Q, in a cohort of patients with forebrain and/or pituitary defects
Data indicate that median methylation levels of BCAN, HOXD1, KCTD8, KLF11, NXPH1, POU4F1, SIM1, and TCF7L1 were >/=30% higher than in normal samples, representing potential biomarkers for tumor diagnosis.
No difference in nuclear beta-catenin signal intensity was found, which may be caused by an alteration in Wnt pathway in microsatellite stable sporadic tumors by unknown mechanisms leading to lower TCF-3, 4 protein expression.
Tcf7l1 defines the border between the neural crest and the prospective forebrain via restriction of the Wnt/beta-catenin signaling gradient.
The authors find that downstream of glycogen synthase kinase 3 inhibition, elevated cMyc and beta-catenin act in parallel to reduce transcription and DNA binding, respectively, of the transcriptional repressor Tcf7l1.
Sox4 and Tcf7l1 form a functional axis that promotes the progression of BCR-ABL-positive acute lymphoblastic leukemia.
The role of Tcf7l1 in mammals is to inhibit the gene regulatory network to ensure the coordination of lineage specification with the dynamic cellular events occurring during gastrulation.
results establish TCF7L1 as a transcriptional hub coordinating cell-cell contact with the transcriptional repression required for adipogenic competency
Tcf3-/- embryos proceed through gastrulation to form mesoderm, but they develop expanded and often duplicated axial mesoderm structures, including nodes and notochords.
E2A-PBX1 interacts directly with the KIX domain of CBP/p300 in the induction of proliferation in primary hematopoietic cells
Tcf3-mediated control of Nanog levels allows stem cells to balance the creation of lineage-committed and undifferentiated cells
These data suggest that in the absence of Wnt signals, Tcf3 may function in skin SCs to maintain an undifferentiated state and, through Wnt signaling, directs these cells along the hair lineage.
Suggest role for Tcf3 in Wnt signaling mediated fetal intestinal villus morphogenesis.
Critical steps in the recovery of the adult thymus include expansion of thymic epithelial cell progenitors and elevated expression of Trp63, cMyc and Tcf3 transcription factors in the thymic stroma.
Tcf3 binds to and represses the Oct4 promoter, and this repressive effect requires both the Groucho and CtBP interacting domains of Tcf3. Tcf3 expression is coregulated with Oct4 and Nanog.
Tcf3 is a cell-intrinsic inhibitor of pluripotent cell self-renewal that functions by limiting steady-state levels of self-renewal factors
Studies present the precise distribution of gene expression of canonical Wnt pathway transcriptional regulators, Tcf1, Lef1, Tcf3, Tcf4 and beta-catenin between
results argue that during anterior-posterior patterning of the mesoderm Tcf7l1 proteins are cell autonomously required to limit Wnt signaling
Results indicate that Tcf7l1 plays an important role in spinal cord progenitor maintenance
This gene encodes a member of the T cell factor/lymphoid enhancer factor family of transcription factors. These transcription factors are activated by beta catenin, mediate the Wnt signaling pathway and are antagonized by the transforming growth factor beta signaling pathway. The encoded protein contains a high mobility group-box DNA binding domain and participates in the regulation of cell cycle genes and cellular senescence.
HMG box transcription factor 3
, transcription factor 7-like 1
, T-cell factor 3
, transcription factor 3
, transcription factor 7-like 1 (T-cell specific, HMG box)
, transcription factor 7-like 2 (T-cell specific, HMG box)
, HMG box transcription factor 3-A
, transcription factor 7-like 1-A
, transcription factor XTCF-3b
, HMG-box transcription factor
, Protein headless
, protein headless
, transcription factor 7-like 1a (T-cell specific, HMG-box)
, transcription factor tcf3