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B-cell acute lymphoblastic leukemia patients with positive E2A-PBX1 (zeige PBX1 Proteine) fusion expression after transplant will have a poor prognosis.
It was concluded that the abnormal expression of endometrial E2A existed in mid-secretory endometrium of women with recurrent miscarriage, and there was a positive correlation between E2A and FOXP3 (zeige FOXP3 Proteine), and E2A and CTLA-4 (zeige CTLA4 Proteine), suggesting the possible regulatory role of E2A in endometrium receptivity.
TCF3 gene silencing inhibits esophageal cancer cells growth and proliferation, suppresses cell cycle progression, and promotes apoptosis.
suggested that the upregulation of TCF3 was a critical prognostic factor for nasopharyngeal carcinoma
Based on results, TCF3 is clearly associated with the progression of cervical squamous cell carcinoma. This is the first time that it has been reported that TCF3 can act as a tumor promoter in cervical cancer and thus might be of great significance in the prognosis of CSCC (zeige CYP11A1 Proteine).
We conclude that inactivation of TCF3 contributes to oncogenic program of classical Hodgkin lymphoma
This is the first time the protein partners of either E2A-PBX1 (zeige PBX1 Proteine) or HOXA9 (zeige HOXA9 Proteine) oncoproteins were identified using an unbiased biochemical approach. The identification of translation initiation factors associated with HOXA9 (zeige HOXA9 Proteine) might indicate a novel function for HOX (zeige MSH2 Proteine) proteins independent of their transcriptional activity.
Poly (ADP-ribose) polymerase (zeige PARP1 Proteine) inhibitors selectively induce cytotoxicity in TCF3-HLF (zeige EPAS1 Proteine)-positive leukemic cells.
MiR (zeige MLXIP Proteine)-138 may be a tumor suppressor and potential prognostic biomarker in cervical cancer. Its downstream target, TCF3, may also regulate cancer development in a reverse manner as miR (zeige MLXIP Proteine)-138.
High levels of TCF3 in gliomas promote glioma development through the Akt (zeige AKT1 Proteine) and Erk (zeige EPHB2 Proteine) pathways.
Mechanistic analysis indicated that E47 activated expression of the transcription factor Spi-B (zeige SPIB Proteine) and the suppressor of cytokine signaling 3 (SOCS3 (zeige SOCS3 Proteine)), which both downregulated Foxp3 (zeige FOXP3 Proteine) expression. These findings demonstrate that the balance of Id3 (zeige ID3 Proteine) and E47 controls the maintenance of Foxp3 (zeige FOXP3 Proteine) expression in Treg cells and, thus, contributes to Treg cell plasticity.
this study identifies E2A target genes in embryonic neural stem cells and demonstrates that E47 regulates neuronal differentiation via p57(KIP2 (zeige CDKN1C Proteine)).
If Gfi1 (zeige ZNF163 Proteine) levels fall below a threshold, Id1 (zeige ID1 Proteine) expression increases and renders E2A unable to function, which prevents hematopoietic progenitors from engaging along the B lymphoid lineage
these data identified E2A and E2-2 (zeige TCF4 Proteine) as central regulators of B cell immunity.
down-regulation of Id3 (zeige ID3 Proteine) in B cells is essential for releasing E2A and E2-2 (zeige TCF4 Proteine), which in a redundant manner are required for antigen-induced B cell differentiation.
Data suggest a novel mechanism of drug resistance in which E2a and PRC2 drive changes in the B-cell epigenome; these alterations attenuate alkylating agent treatment-induced apoptosis.
These findings suggest that miR (zeige MLXIP Proteine)-506-3p played an important role in regulating NSC proliferation and differentiation via targeting TCF3 (zeige TCF7L1 Proteine), and provide a promising avenue for future in-depth research into the functions of miR (zeige MLXIP Proteine)-506-3p and TCF3 (zeige TCF7L1 Proteine) in nervous system development.
Conditional expression of E2A-HLF (zeige HLF Proteine) induces B-cell precursor death and myeloproliferative-like disease in knock-in mice.
Upregulation of E12/E47 by HBx ultimately and concomitant repression of E-cadherin (zeige CDH1 Proteine) expression led to epithelial-mesenchymal transition in human hepatocytes.
Mechanistically, E47 repressed the expression of several astrocyte-specific genes in adult NSPCs.
Data indicte that Tcf-1 (zeige HNF1A Proteine) and Lef-1 (zeige LEF1 Proteine) exhibit a function in the axis induction assay, which is lacking in Tcf-3 and -4.
This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1\;19), with PBX1), childhood leukemia (t(19\;19), with TFPT) and acute leukemia (t(12\;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9.
VDR interacting repressor
, class B basic helix-loop-helix protein 21
, helix-loop-helix protein HE47
, immunoglobulin transcription factor 1
, kappa-E2-binding factor
, negative vitamin D response element-binding protein
, transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
, transcription factor E2-alpha
, transcription factor ITF-1
, vitamin D receptor-interacting repressor
, transcription factor 3
, immunoglobulin enhancer-binding factor E12/E47
, transcription factor A1
, transcription factor E2a
, pancreas specific transcription factor 1c
, transcription regulator Pan
, transcription factor XE12/XE47
, class A basic helix-loop-helix transcription factor G12
, helix-loop-helix protein E12
, helix-loop-helix protein E47
, transcription factor 7-like 1 (T-cell specific, HMG-box)