TCF3 Protein (Transcript Variant 2) (Myc-DYKDDDDK Tag)

Produktnummer ABIN2733358

Produktdetails

Target: TCF3 (Transcription Factor 3 (E2A Immunoglobulin Enhancer Binding Factors E12/E47) (TCF3))

Protein-Typ: Recombinant

Proteineigenschaft: Transcript Variant 2

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses TCF3 Protein ist gelabelt mit Myc-DYKDDDDK Tag.

Applikation: Antibody Production (AbP), Standard (STD)

Produktmerkmale:

• Recombinant human TCF3 / E2A (transcript variant 2) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Reinheit: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Anwendungsinformationen

Applikationshinweise: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Kommentare:

The tag is located at the C-terminal.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Antigendetails

Target: TCF3 (Transcription Factor 3 (E2A Immunoglobulin Enhancer Binding Factors E12/E47) (TCF3))

Andere Bezeichnung: Tcf3,e2a (TCF3 Produkte)

Synonyme: E2A Protein, E47 Protein, ITF1 Protein, TCF-3 Protein, VDIR Protein, bHLHb21 Protein, tcf3a Protein, zgc:113045 Protein, A1 Protein, AA408400 Protein, ALF2 Protein, AW209082 Protein, E12 Protein, E12/E47 Protein, ME2 Protein, Pan1 Protein, Pan2 Protein, Tcfe2a Protein, bhlhb21 Protein, e2a Protein, itf1 Protein, tcfe2a Protein, vdir Protein, xtcf-3 Protein, xtcf3 Protein, G12 Protein, TCF7L1 Protein, XE3 Protein, transcription factor 3 Protein, transcription factor 3b Protein, transcription factor 3 L homeolog Protein, transcription factor E2a Protein, TCF3 Protein, tcf3b Protein, Tcf3 Protein, tcf3.L Protein, tcfe2a Protein

Hintergrund: This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(119), with PBX1), childhood leukemia (t(1919), with TFPT) and acute leukemia (t(1219), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9.

Molekulargewicht: 67.1 kDa

NCBI Accession: NP_001129611

Pathways: WNT Signalweg, Stem Cell Maintenance, Regulation of Muscle Cell Differentiation, Production of Molecular Mediator of Immune Response