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anti-Human GPBAR1 Antikörper:
anti-Rat (Rattus) GPBAR1 Antikörper:
anti-Mouse (Murine) GPBAR1 Antikörper:
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Human Monoclonal GPBAR1 Primary Antibody für CyTOF, FACS - ABIN4899058
Yoneno, Hisamatsu, Shimamura, Kamada, Ichikawa, Kitazume, Mori, Uo, Namikawa, Matsuoka, Sato, Koganei, Sugita, Kanai, Hibi: TGR5 signalling inhibits the production of pro-inflammatory cytokines by in vitro differentiated inflammatory and intestinal macrophages in Crohn's disease. in Immunology 2013
Human Polyclonal GPBAR1 Primary Antibody für IHC (p) - ABIN4359103
Alemi, Poole, Chiu, Schoonjans, Cattaruzza, Grider, Bunnett, Corvera: The receptor TGR5 mediates the prokinetic actions of intestinal bile acids and is required for normal defecation in mice. in Gastroenterology 2012
RYGB increased circulating bile acids, ileal Takeda G protein-coupled receptor 5 (zeige XCR1 Antikörper) (TGR5) and mTORC1 signaling activity, as well as GLP-1 (zeige GCG Antikörper) production in both mice and human subjects. Inhibition of ileal mTORC1 signaling by rapamycin significantly attenuated the stimulation of bile acid secretion, TGR5 expression and GLP-1 (zeige GCG Antikörper) synthesis induced by RYGB in lean and diet-induced obese mice.
TGR5 is strongly expressed in collecting ducts, distal convoluted tubules and thin loop of Henle. TGR5 protein and mRNA expression were notably decreased in clear cell renal cell carcinomas and may be helpful in differentiating these tumors from other renal cell carcinomas.
The findings suggest that activation of TGR5 promoted mitochondrial biogenesis in endothelial cells, which is mediated by the CREB (zeige CREB1 Antikörper)/PGC (zeige PGC Antikörper)-1a signaling pathway.
Higher-order oligomers, likely with a tetramer organization, are formed from dimers, the smallest unit suggested for TGR5 Y111A variants.
Data suggest that TGR5 and FXR (zeige NR1H4 Antikörper) in intestinal mucosa are important for glucose homeostasis, in particular in metabolic disorders such as type 2 diabetes and obesity. (TGR5 = membrane-type receptor for bile acids TGR5; FXR (zeige NR1H4 Antikörper) = farnesoid X receptor (zeige xpr1 Antikörper)) [REVIEW; Congress as Topic]
The authors conclude that taurodeoxycholic acid-induced DNA damage may depend on the activation of TGR5, CREB (zeige CREB1 Antikörper) and NOX5 (zeige NOX5 Antikörper)-S. It is possible that in Barrett's patients bile acids may activate NOX5 (zeige NOX5 Antikörper)-S and increase reactive oxygen species (ROS (zeige ROS1 Antikörper)) production via activation of TGR5 and CREB (zeige CREB1 Antikörper). NOX5 (zeige NOX5 Antikörper)-S-derived ROS (zeige ROS1 Antikörper) may cause DNA damage, thereby contributing to the progression from Barrett's esophagus to esophageal adenocarcinoma.
GPBAR1 is expressed in advanced gastric cancers and its expression correlates with markers of epithelial-mesenchymal transition
TGR5 activation induces mitochondrial biogenesis and prevents renal oxidative stress and lipid accumulation, establishing a role for TGR5 in inhibiting Kidney Disease in Obesity and Diabetes Mellitus.
TGR5 exhibits significantly higher expression in NSCLC tumor samples and facilitates the growth and metastasis of NSCLC by activating the JAK2 (zeige JAK2 Antikörper)/STAT3 (zeige STAT3 Antikörper) signaling pathway.
TGR5 may have a role in the progression from Barrett's Esophagus to high-grade dysplasia and esophageal adenocarcinoma
TGR5 agonism induces NO production via Akt (zeige AKT1 Antikörper) activation and intracellular Ca(2 (zeige CA2 Antikörper)+) increase in vascular endothelial cells, and this function inhibits monocyte adhesion in response to inflammatory stimuli.
TGR5 has been linked to signaling pathways involved in metabolism, cell survival, proliferation and apoptosis, which suggest a possible role of TGR5 in cancer development.
G-protein coupled bile acid receptor 1 (TGR5) is required for cold-induced beiging of subcutaneous white adipose tissue (scWAT).
Work is the first to provide evidence for a TGR5-inhibited inflammatory response in ischemia/reperfusion injury through suppression of the TLR4 (zeige TLR4 Antikörper)-NF-kappaB (zeige NFKB1 Antikörper) pathway.
findings show GPBAR1 is essential for maintaining intestinal immune homeostasis and that its activation in the setting of inflammation reverses the immune dysfunction that occurs in rodent models of colitis
Data suggest that FXR (zeige NR1H4 Antikörper) and TGR5 expression is down-regulated in aging kidney; caloric restriction prevents these age-related changes. Additionally, in long-lived Ames dwarf (zeige PROP1 Antikörper) mice, renal FXR (zeige NR1H4 Antikörper) and TGR5 expression is up-regulated. Treatment of aged mice with dual FXR (zeige NR1H4 Antikörper)/TGR5 agonist reverses age-related changes in kidney structure/function. (FXR (zeige NR1H4 Antikörper) = farnesoid X activated receptor (zeige NR1H4 Antikörper); TGR5 = G protein-coupled bile acid receptor 1)
GPBAR1/TGR5 receptor agonist, tauroursodeoxycholic acid, has anti-inflammatory effects in microglial cells.
Vertical sleeve gastrectomy achieves its postoperative therapeutic effects through enhanced TGR5 signaling.
These results suggest that TGR5 contributes to the glucoregulatory benefits of vertical sleeve gastrectomy surgery by promoting metabolically favourable shifts in the circulating bile acid pool.
findings uncovered a novel mechanism in which INT-767 activation of FXR (zeige NR1H4 Antikörper) induces Tgr5 gene expression and increases Ca(2 (zeige CA2 Antikörper)+) levels and cAMP activity to stimulate GLP-1 (zeige GCG Antikörper) secretion and improve hepatic glucose and lipid metabolism in high-fat diet-induced obese mice.
The results suggest that TGR5 activation mediates cross-talk between alpha- and beta-cells by switching from glucagon (zeige GCG Antikörper) to GLP-1 (zeige GCG Antikörper) to restore beta- cell mass and function under hyperglycemic conditions.
TGR5 is an important mediator of bile acid-induced cholangiocyte proliferation in vivo and in vitro. Furthermore, TGR5 protects cholangiocytes from death receptor-mediated apoptosis.
This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein.
G-protein coupled bile acid receptor 1
, G-protein coupled bile acid receptor BG37
, G-protein coupled receptor GPCR19
, membrane bile acid receptor
, membrane-type receptor for bile acids
, G protein-coupled receptor TGR5
, G protein-coupled receptor
, G protein-coupled bile acid receptor 1