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anti-Human FZD8 Antikörper:
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Dog (Canine) Polyclonal FZD8 Primary Antibody für WB - ABIN2776728
Lu, Yamamoto, Ortega, Baltimore: Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth. in Cell 2004
Show all 3 Pubmed References
Human Polyclonal FZD8 Primary Antibody für ICC, IF - ABIN250857
Sugimura, He, Venkatraman, Arai, Box, Semerad, Haug, Peng, Zhong, Suda, Li: Noncanonical Wnt signaling maintains hematopoietic stem cells in the niche. in Cell 2012
Show all 2 Pubmed References
Human Polyclonal FZD8 Primary Antibody für ELISA, WB - ABIN563593
Klee, Finlay, McDonald, Attewell, Hebrink, Dyer, Love, Vasmatzis, Li, Beechem, Klee: Bioinformatics methods for prioritizing serum biomarker candidates. in Clinical chemistry 2007
Dog (Canine) Polyclonal FZD8 Primary Antibody für IHC (p), ELISA - ABIN547568
Keay, Szekely, Conrads, Veenstra, Barchi, Zhang, Koch, Michejda: An antiproliferative factor from interstitial cystitis patients is a frizzled 8 protein-related sialoglycopeptide. in Proceedings of the National Academy of Sciences of the United States of America 2004
Expression of FZD8 is directly correlated with ERG expression in prostate cancer. Furthermore, we show that ERG directly targets and activates FZD8 by binding to its promoter. This activation is specific to ETS transcription factor ERG and not ETV1.
FZD8 forms a TGF-beta-regulated complex with TGF-beta receptors that is mediated by the extracellular domains of FZD8 and TGFBR1
In OS tissues, miR-520b was inversely correlated with FZD8 expression. FZD8 was upregulated in human spinal OS tissues and cell lines.
miR-375 functions as a tumor-suppressive microRNA by directly acting upon FZD8, which may serve as a new therapeutic target to inhibit tumor metastasis in colorectal cancer
Elevated expression of TP53 target FZD8 promoted prostate cancer bone metastasis by activating the canonical Wnt/beta-catenin signaling pathway.
these findings suggest that miR-100 suppresses the migration and invasion of breast cancer cells by targeting FZD-8 and inhibiting Wnt/b-catenin signaling pathway and manipulation of miR-100 may provide a promoting therapeutic strategy for cancer breast treatment.
Frizzled-8 has an important pro-inflammatory role and suggest that its expression is related to chronic bronchitis.
report the discovery of a human-accelerated regulatory enhancer (HARE5) of FZD8, a receptor of the Wnt pathway implicated in brain development and size
Study concludes that expression of Fzd8 is repressed in multiple cancers and suggest it may have a role as a tumor suppressor.
c-Met upregulated FZD8 through the ERK/c-Fos cascade in HN-CSC. Taken together, our results offer a preclinical proof-of-concept for targeting the c-Met/FZD8 signaling axis as a CSC-directed therapy to improve HNSCC treatment
We demonstrated an activation of Wnt-2 signaling via the Frizzled-8 receptor in non-small cell lung cancer cells
These observations suggest that c-Jun is involved in APF-mediated inhibition for bladder tumor cell growth
APF has been shown to be a nine-residue frizzled-8 protein-related sialoglycopeptide. Subsequent research has gradually clarified the molecular mechanisms underlying the profound antiproliferative effect of APF.
Soluble FZC18 and Wnt3a physically interact in a cell-free system and soluble FZC18 binds the frizzled 1 and 8 receptors.
analysis of the frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6
molecular model of the Wnt protein binding site on the surface of dimeric CRD domain of the Fzd8 receptor
Data suggest that Sizzled is unlikely able to antagonize Wnt signaling; however, structure of Sizzled provides a framework for understanding full-length structure of secreted Frizzled-related proteins such as frizzled-8 and their interaction with and antagonism of Wnt proteins such as Wnt-8.
Xfz8 is involved in the process of normal epithelium formation in the developing pronephric duct and tubules after specific
Human-chimpanzee differences in a FZD8 enhancer (HARE5) alter cell-cycle dynamics in the developing neocortex.
Increasing amounts of soluble Frizzled8-cysteine-rich-domain protein modulated Wnt3a signaling in a biphasic manner.
Fzd8 and beta-catenin negatively regulate osteoclast differentiation independent of osteoblasts.
Study shows Flamingo (Fmi) and Frizzled (Fz) 8, members of noncanonical Wnt signaling, both express in and functionally maintain quiescent long-term hematopoietic stem cells.
study presents the structure of Xenopus Wnt8 (XWnt8) in complex with the mouse Fz8-cysteine-rich domain to a resolution of 3.25 A
studies suggest a dose-dependent regulation of signaling by Fz5 and Fz8 in optic fissure/disc formation and progenitor expansion
A major role for frizzled 4 and frizzled 8 in controlling ureteric growth in the developing kidney.
Several lines of evidence that the mouse Cristin/R-spondin family proteins function as Fzd8 and LRP6 receptor ligands and induce the canonical Wnt/beta-catenin signaling pathway, leading to TCF-dependent gene activation, are presented.
Molecular modeling of the complex between the xWNT8 protein and the CRD domain of mFZD8
Insulin-like growth-factor-binding protein-4 physically interacted with a Wnt receptor, Frizzled 8 (Frz8), and a Wnt co-receptor, low-density lipoprotein receptor-related protein 6 (LRP6), and inhibited the binding of Wnt3A to Frz8 and LRP6
This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.
frizzled 8, seven transmembrane spanning receptor
, frizzled homolog 8
, frizzled 8
, frizzled 8 protein
, frizzled class receptor 8b
, frizzled homolog 6
, frizzled homolog 8b