anti-DVL1 (DVL1) Antikörper

Human Dishevelled, Dsh Homolog 1 (Drosophila) (DVL1) Interaktionspartner

1. Lack of DVL (zeige DVL2 Antikörper) prevents NEK2 (zeige NEK2 Antikörper)-controlled dissolution of loose centrosomal linker and subsequent centrosomal separation. Increased DVL (zeige DVL2 Antikörper) levels, in contrast, sequester centrosomal NEK2 (zeige NEK2 Antikörper) and mimic monopolar spindle defects induced by a dominant negative version of this kinase.

2. These results identify USP4 (zeige USP4 Antikörper) as a novel regulator of Dvl (zeige DVL2 Antikörper) in Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) signal and show its involvement in Wnt3a (zeige WNT3A Antikörper)-induced osteoblast differentiation

3. Authors conclude that the planar cell polarity (PCP (zeige PRCP Antikörper)) pathway contributes significantly to the motility and hence the invasiveness of glioblastoma multiforme (GBM) cells, and that Nrdp1 (zeige RNF41 Antikörper) acts as a negative regulator of PCP (zeige PRCP Antikörper) signaling by inhibiting Dvl (zeige DVL2 Antikörper) through a novel polyubiquitination mechanism.

4. The DEP (zeige ZDHHC21 Antikörper) domain of Dishevelled (zeige DVL2 Antikörper) undergoes a conformational switch, from monomeric to swapped dimer, to trigger DIX domain-dependent polymerization and signaling to beta-catenin (zeige CTNNB1 Antikörper).

5. two mutually exclusive functions of the DEP (zeige ZDHHC21 Antikörper) domain in Wnt (zeige WNT2 Antikörper) signal transduction - binding to Frizzled to recruit Dishevelled (zeige DVL2 Antikörper) to the receptor complex, is reported.

6. we show that Wnt5a (zeige WNT5A Antikörper) rapidly represses rDNA gene transcription in breast cancer cells and generates a chromatin state with reduced transcription of rDNA by RNA polymerase I (zeige POLR1C Antikörper) (Pol I). These effects were specifically dependent on Dishevelled1 (DVL1), which accumulates in nucleolar organizer regions (NORs) and binds to rDNA regions of the chromosome.

7. Data show that dishevelled (zeige DVL2 Antikörper) proteins DVL1, 2 and 3 were exclusively expressed in chronic lymphatic leukaemia (CLL) cells as compared to normal peripheral blood mononuclear cells (PBMCs).

8. The secreted frizzled-related protein (zeige SFRP2 Antikörper) and disheveled protein family members appear to be actively involved in the pathogenesis of primary testicular germ cell tumors.

9. Data show that receptor for activated C kinase 1 (RACK1 (zeige GNB2L1 Antikörper)) interacts with Dishevelled (Dvl (zeige DVL2 Antikörper)) proteins and promotes their lysosomal degradation, and this effect is enhanced by autophagy induction.

10. TMEM88 stimulated triple negative breast cancer cell invasion by interacting with DVLl.

Mouse (Murine) Dishevelled, Dsh Homolog 1 (Drosophila) (DVL1) Interaktionspartner

1. Data show that the peptide binding pocket of the Dishevelled 1 (Dvl1) PDZ domain (zeige INADL Antikörper) is stabilized upon CXXC finger 5 protein (CXXC5 (zeige CXXC5 Antikörper)) binding.

2. Here we show that the peptide-binding pocket of the Dvl PDZ domain (zeige INADL Antikörper) can be occupied by Dvl's own highly conserved C-terminus, inducing a closed conformation.

3. The interaction of Dvl1 with Syt-1 (zeige SYT1 Antikörper), which is regulated by Wnts, modulates neurotransmitter release.

4. findings indicate that Dvl-1 may be an underlying participant of oxidative stress induced (zeige SQSTM1 Antikörper) by selenium deficiency

5. These results support a novel cell-autonomous postsynaptic role for Dact1 (zeige DACT1 Antikörper), in cooperation with Dishevelled-1 and possibly Disrupted in Schizophrenia-1 (zeige DISC1 Antikörper), in the formation of synapses on cortical interneuron dendrites.

6. we show that Dvl-1 expression is restricted to OSNs in the dorsal recess of the nasal cavity, and labels a unique subpopulation of glomeruli. Dvl-2 (zeige DVL2 Antikörper) and Dvl-3 (zeige DVL3 Antikörper) have a widespread distribution in both the olfactory epithelium and olfactory bulb .

7. Fuzzy appears to control subcellular localization of the core PCP (zeige BMP1 Antikörper) protein Dishevelled (zeige DVL2 Antikörper), recruiting it to Rab8 (zeige RAB8A Antikörper)-positive vesicles and to the basal body and cilium. We show that loss of Fuzzy results in inhibition of PCP (zeige BMP1 Antikörper) signaling

8. A Wnt5a (zeige WNT5A Antikörper)--> Dvl PCP (zeige BMP1 Antikörper) signaling cascade may regulate actin polymerization and protrusive cell behavior in the caudal (zeige CAD Antikörper) splanchnic mesoderm to promote second heart field deployment, outflow tract lengthening and cardiac looping.

9. Findings indicate that Daple (zeige CCDC88C Antikörper) interacts with Dishevelled (zeige DVL2 Antikörper) to direct the Dishevelled (zeige DVL2 Antikörper)/protein kinase (zeige CDK7 Antikörper) lambda protein complex to activate Rac (zeige AKT1 Antikörper), which in turn mediates the non-canonical Wnt (zeige WNT2 Antikörper) signalling pathway required for cell migration.

10. The antagonistic functions of Vangl2 (zeige VANGL2 Antikörper) and Dvl1 allow sharpening of planar cell polarity signaling locally on the tips of the filopodia to sense directional cues, Wnts, eventually causing turning of growth cones.

Xenopus laevis Dishevelled, Dsh Homolog 1 (Drosophila) (DVL1) Interaktionspartner

1. Different Dvl (zeige DVL2 Antikörper) proteins (Dvl1, Dvl2 (zeige DVL2 Antikörper), Dvl3 (zeige DVL3 Antikörper)) and the composition of dishevelled (zeige DVL2 Antikörper)-beta-arrestin protein complexes contribute to the specific activation of individual branches of Wnt (zeige WNT2 Antikörper) signaling in Xenopus gastrulation.