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anti-Human DKK4 Antikörper:
anti-Mouse (Murine) DKK4 Antikörper:
anti-Rat (Rattus) DKK4 Antikörper:
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Human Polyclonal DKK4 Primary Antibody für IHC (p), WB - ABIN388357
Matsui, Yamaguchi, Maekawa, Miyazaki, Takano, Uetake, Inoue, Otaka, Otsuka, Sato, Yamashita, Takahashi, Enomoto: DICKKOPF-4 and -2 genes are upregulated in human colorectal cancer. in Cancer science 2009
Show all 3 Pubmed References
Human Polyclonal DKK4 Primary Antibody für ELISA, WB - ABIN249465
Krupnik, Sharp, Jiang, Robison, Chickering, Amaravadi, Brown, Guyot, Mays, Leiby, Chang, Duong, Goodearl, Gearing, Sokol, McCarthy: Functional and structural diversity of the human Dickkopf gene family. in Gene 1999
We found that TCF7L1 (zeige TCF3 Antikörper) recruits the C-terminal binding protein (CtBP (zeige CTBP2 Antikörper)) and histone deacetylase 1 (HDAC1 (zeige HDAC1 Antikörper)) to the DKK4 promoter to repress DKK4 gene expression. In the absence of TCF7L1 (zeige TCF3 Antikörper), TCF7L2 (zeige TCF7L2 Antikörper) and beta-catenin (zeige CTNNB1 Antikörper) occupancy at the DKK4 promoter is stimulated and DKK4 expression is increased. These findings uncover a critical role for TCF7L1 (zeige TCF3 Antikörper) in repressing DKK4 gene expression to promote the oncogenic potential of CRCs.
DKK4 expression is significantly upregulated in human masticatory mucosa during wound healing
DKK4 may have function on the development and progression of pancreatic cancer.
The recurrence of benign tumors of mammary gland occurred predominantly in women-carriers of mutant alleles with polymorphism rs8190924 of gene GSR (zeige GSR Antikörper) and AA rs3763511of gene DKK4.
DKK4 upregulated by T3/TR antagonizes the Wnt (zeige WNT2 Antikörper) signal pathway to suppress tumor cell progression
rs3923086 in AXIN2 (zeige AXIN2 Antikörper) and rs3763511 in DKK4 that did not show any association in the overall population were significantly associated with early on-set and estrogen receptor (zeige ESR1 Antikörper) negative breast cancers, respectively.
It would appear that deregulation of the WNT (zeige WNT2 Antikörper) pathway by overexpression of DKK4 may further impair WNT (zeige WNT2 Antikörper) signaling and lead to Anorectal malformations.
Our findings suggest a potential tumour suppressive role of DKK4 as well as that of an important regulator of HCC (zeige FAM126A Antikörper).
Found the unique expression of the Wnt (zeige WNT2 Antikörper) antagonist DKK4 in SW480APC, but not parental SW480 cell-derived exosomes. Upregulation of DKK4 in SW480APC cells was confirmed by RT-PCR, immunoblotting, and immunogold electron microscopy.
The TR/DKK4/Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) cascade influences the proliferation and migration of hepatoma cells during the metastasis process and support a tumor suppressor role of the thyroid hormone receptor (zeige THRA Antikörper).
the dynamic state of Dkk4 itself and its interaction with Lrp6 (zeige LRP6 Antikörper) modulates Wnt (zeige WNT2 Antikörper) function during Meibomian gland development, with a novel limitation of Dkk4 action by proteolytic cleavage.
sweat gland development shows a relay of regulatory steps initiated by Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) - itself modulated by Dkk4 - with subsequent participation of Eda (zeige EDA Antikörper) and Shh (zeige SHH Antikörper) pathways.
These results showed that Dkk4 functions as an inhibitor of osteoblastogenesis through Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) signaling, providing new insights into the relationship between Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) signaling and Dkk4 in bone formation.
Dkk4 affects an auxiliary pathway for Eda (zeige EDA Antikörper)-independent development of secondary hair
Dkk4 acts in a negative feedback loop to attenuate canonical Wnt (zeige WNT2 Antikörper) signaling and may facilitate a switch to the non-canonical Wnt (zeige WNT2 Antikörper) planar cell polarity pathway that is involved in cell movements during morphogenesis.
Microarray profiling of genes differentially regulated by short exposure to recombinant Eda-A1 (zeige EDA Antikörper) in embryonic eda (zeige EDA Antikörper)(-/-) skin explants, was performed to identify direct targets of ectodysplasin pathway.
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. Activity of this protein is modulated by binding to the Wnt co-receptor and the co-factor kremen 2.
, dickkopf-related protein 4
, dickkopf homolog 4
, LOW QUALITY PROTEIN: dickkopf-related protein 4