The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Alternative names and synonyms associated with SPHK1
Sphingosine kinase 1 (Sk1) ELISA Kit
sphingosine kinase 1 (SPHK1) ELISA Kit
sphingosine kinase 1 L homeolog (sphk1.L) ELISA Kit