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SPHK1 ELISA Kit

SPHK1 Reaktivität: Human AA 1-384 Colorimetric Sandwich ELISA
Produktnummer ABIN5510666
  • Target Alle SPHK1 ELISA Kits anzeigen
    SPHK1 (Sphingosine Kinase 1 (SPHK1))
    Bindungsspezifität
    AA 1-384
    Reaktivität
    • 3
    • 1
    • 1
    Human
    Nachweismethode
    Colorimetric
    Methodentyp
    Sandwich ELISA
    Applikation
    ELISA
    Verwendungszweck
    Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human SPHK1
    Marke
    PicoKine™
    Analytische Methode
    Quantitative
    Spezifität
    Expression system for standard: NSO
    Immunogen sequence: M1-L384
    Kreuzreaktivität (Details)
    There is no detectable cross-reactivity with other relevant proteins.
    Produktmerkmale

    Tissue Specificity: Widely expressed with highest levels in adult liver, kidney, heart and skeletal muscle. .

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  • Plattentyp
    Pre-coated
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)
    Haltbarkeit
    12 months
  • Target Alle SPHK1 ELISA Kits anzeigen
    SPHK1 (Sphingosine Kinase 1 (SPHK1))
    Andere Bezeichnung
    SPHK1 (SPHK1 Produkte)
    Synonyme
    CG1747 ELISA Kit, Dmel\\CG1747 ELISA Kit, SK1 ELISA Kit, Sphk1 ELISA Kit, SPHK1 ELISA Kit, F18E5.160 ELISA Kit, F18E5_160 ELISA Kit, sphingosine kinase 1 ELISA Kit, SPHK ELISA Kit, 1110006G24Rik ELISA Kit, Sk1 ELISA Kit, Spk1 ELISA Kit, Sphingosine kinase 1 ELISA Kit, sphingosine kinase 1 ELISA Kit, sphingosine kinase 1 L homeolog ELISA Kit, Sk1 ELISA Kit, SPHK1 ELISA Kit, sphk1.L ELISA Kit, Sphk1 ELISA Kit
    Hintergrund

    Protein Function: Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol. .

    Background: Sphingosine kinase 1 is an enzyme that in humans is encoded by the SPHK1 gene. The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1- phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

    Synonyms: Sphingosine kinase 1,SK 1,SPK 1,2.7.1.91,SPHK1,SPHK, SPK,

    Full Gene Name: Sphingosine kinase 1

    Cellular Localisation: Cytoplasm. Nucleus. Cell membrane. Translocated from the cytoplasm to the plasma membrane in a CIB1-dependent manner.
    UniProt
    Q9NYA1
    Pathways
    VEGF Signaling
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