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Utrophin Produkte

(Utrophin (UTRN))
This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. The protein encoded by this gene is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore, may serve as a potential therapeutic alternative to muscular dystrophy which is caused by mutations in the dystrophin gene. Alternative splicing of the utrophin gene has been described\; however, the full-length nature of these variants has not yet been determined. [provided by RefSeq, Jul 2008].

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Ausgewählte Utrophin Kategorien

Utrophin Antikörper

High quality antibodies with extensive validation data.

Utrophin ELISA Kits

Reliable ELISA kits for a wide range of species.

Utrophin Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene Utrophin Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Applikation WB, IHC, IP, ICC
Validierungen
  • (8)
Kat. Nr. ABIN7443953
Menge 100 μL
Datenblatt Datenblatt
Reaktivität Human
Applikation WB, ELISA, IF
Validierungen
  • (3)
Kat. Nr. ABIN563360
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Mouse
Applikation WB, IF
Validierungen
  • (5)
  • (3)
Kat. Nr. ABIN968237
Menge 50 μg
Datenblatt Datenblatt

Empfohlene Utrophin ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6971089
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6960406
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Mouse
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6960407
Menge 96 tests
Datenblatt Datenblatt

Empfohlene Utrophin Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN1324869
Menge 10 μg
Datenblatt Datenblatt
Reaktivität Human
Source Escherichia coli (E. coli)
Validierungen
Kat. Nr. ABIN7417648
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Mouse
Source Escherichia coli (E. coli)
Validierungen
Kat. Nr. ABIN7408324
Menge 100 μg
Datenblatt Datenblatt

Neueste Publikationen zu unseren Utrophin Produkten

Gramolini, Burton, Tinsley, Ferns, Cartaud, Cartaud, Davies, Lunde, Jasmin: "Muscle and neural isoforms of agrin increase utrophin expression in cultured myotubes via a transcriptional regulatory mechanism." in: The Journal of biological chemistry, Vol. 273, Issue 2, pp. 736-43, (1998) (PubMed).

Deconinck, Rafael, Skinner, Brown, Potter, Metzinger, Watt, Dickson, Tinsley, Davies: "Utrophin-dystrophin-deficient mice as a model for Duchenne muscular dystrophy." in: Cell, Vol. 90, Issue 4, pp. 717-27, (1997) (PubMed).

Grady, Teng, Nichol, Cunningham, Wilkinson, Sanes: "Skeletal and cardiac myopathies in mice lacking utrophin and dystrophin: a model for Duchenne muscular dystrophy." in: Cell, Vol. 90, Issue 4, pp. 729-38, (1997) (PubMed).

Guo, Nichol, Merlie: "Cloning and expression of full length mouse utrophin: the differential association of utrophin and dystrophin with AChR clusters." in: FEBS letters, Vol. 398, Issue 2-3, pp. 259-64, (1997) (PubMed).

Tinsley, Blake, Roche, Fairbrother, Riss, Byth, Knight, Kendrick-Jones, Suthers, Love: "Primary structure of dystrophin-related protein." in: Nature, Vol. 360, Issue 6404, pp. 591-3, (1993) (PubMed).

Synonyme und alternative Namen zu Utrophin

utrophin L homeolog (utrn.L), utrophin (UTRN), utrophin (LOAG_03796), utrophin (utrn), utrophin (LOC100551145), utrophin (Utrn), AA589569, DKFZp469A0710, dmdl, DMDL, Dmdl, drp, DRP, drp1, DRP1

Bezeichner auf Proteinebene für Utrophin

  • utrophin
  • utrophin, or dystrophin-related protein 1
  • DRP-1
  • dystrophin-related protein 1
  • utrophin (homologous to dystrophin)
  • G-utrophin
  • urotrophin
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