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data presented in this study characterize UXT as a novel repressor of Notch (zeige NOTCH1 Proteine) signaling, shedding new light on the molecular regulation of angiogenesis.
Our study has revealed the first in vivo function for UXT in the mammalian germline as a regulator of distinct transcriptional programs in SSCs and differentiating spermatogonia.
UXT Is a LOX (zeige LOX Proteine)-PP Interacting Protein That Modulates Estrogen Receptor Alpha (zeige ESR1 Proteine) Activity in Breast Cancer Cells.
UXT-V1 represents a novel integral component of the MAVS (zeige MAVS Proteine) signalosome on mitochondria, mediating the innate antiviral signal transduction.
these results suggest that Als2 is a binding partner of Uxt and Als2/Uxt interaction could be important for the activation of Nf-kappaB (zeige NFKB1 Proteine) pathway.
Ubiquitously expressed transcript, UXT-V1, is a novel regulator of TNF (zeige TNF Proteine)-induced apoptosis. It protects cells against TNF (zeige TNF Proteine)-induced apoptosis through modulating complex II formation.
Uxt is a novel and essential cofactor in the NF-kappa B (zeige NFKB1 Proteine) transcriptional enhanceosome.
EZH1 (zeige EZH1 Proteine), SUZ12 and UXT work synergistically to regulate pathway activation in the nucleus.
we describe the identification of UXT as a novel MDMX (zeige MDM4 Proteine)-interacting protein
UXT is a binding protein of PIAS2 (zeige PIAS2 Proteine), and interaction between PIAS2 (zeige PIAS2 Proteine) and UXT may be important for the transcriptional activation of AR.
Art27 interacts with GATA4 (zeige GATA4 Proteine), FOG2 and NKX2.5 (zeige NKX2-5 Proteine) and is a novel co-repressor of cardiac genes.
Knockdown of UXT expression in Treg cells results in a less-suppressive phenotype.
VHL (zeige VHL Proteine)-UXT interaction and VHL (zeige VHL Proteine)-induced ubiquitination of androgen receptor(AR (zeige AR Proteine)) regulate transcriptional activation of the AR.
Data found that the UXT isoforms elicit dual opposing regulatory effects on SARM (zeige SARM1 Proteine)-induced apoptosis.
Epstein-Barr virus BGLF4 kinase downregulates NF-kappaB (zeige NFKB1 Proteine) transactivation through phosphorylation of coactivator UXT
Loss of ART-27 enhances expression of many androgen-regulated genes, suggesting that ART-27 inhibits gene expression, and nuclear ART-27 expression was lost in the majority of AR-positive recurrent prostate cancers.
The protein encoded by this gene functions as a cofactor that modulates androgen receptor-dependent transcription, and also plays a critical role in tumor necrosis factor-induced apoptosis. Expression of this gene may play a role in tumorigenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
, ubiquitously-expressed transcript
, ubiquitously expressed transcript protein
, SKP2-associated alpha PFD 1
, androgen receptor trapped clone 27 protein