anti-Heart and Neural Crest Derivatives Expressed 2 (HAND2) Antikörper

Human Heart and Neural Crest Derivatives Expressed 2 (HAND2) Interaktionspartner

1. These findings indicate that HAND2 loss-of-function mutation contributes to human CHD (zeige CHDH Antikörper), perhaps via its interaction with GATA4 (zeige GATA4 Antikörper) and NKX2.5 (zeige NKX2-5 Antikörper).

2. HAND2 and microRNA-1 facilitated the early progress of human induced cardiomyocyte-like cells reprogramming.

3. this study is the first to report the association of a HAND2 loss-of-function mutation with an increased vulnerability to tetralogy of Fallot in humans, which provides novel insight into the molecular mechanism underpinning congenital heart disease

4. HAND2-mediated proteolysis negatively regulates the function of estrogen receptor alpha (zeige ESR1 Antikörper).

5. suggest that HAND2 plays a key role in the regulation of progestin-induced decidualization of human endometrial stromal cells.

6. Reduced protein expression of HAND2 in the myenteric plexus of the aganglionic segment would suggest that HAND2 was involved in the pathogenesis of Hirschsprung disease.

7. Increased HAND2 methylation was a feature of premalignant endometrial lesions and was seen to parallel a decrease in RNA and protein levels.

8. Overdosage of Hand2 causes limb and heart defects in the human chromosomal disorder partial trisomy distal 4q.

9. No evidence of linkage between HAND2 and CL/P was obtained. Levelss of exclusion were obtained with different inheritance models. results did not support HAND2 in CL/P

10. Expression analyses on both Hand2 conditionally null and hypomorphic backgrounds demonstrate that Hand2 is required for reporter activation in a gene dosage-dependent manner during sympathetic neurogenesis.

Mouse (Murine) Heart and Neural Crest Derivatives Expressed 2 (HAND2) Interaktionspartner

1. HAND2 directly regulates the molecular cascades initiating atrioventricular canal cardiac valve development.

2. Ptn (zeige PTN Antikörper) may play a vital role in the progesterone-induced decidualization pathway via C/EBPB (zeige CEBPB Antikörper)-cyclic AMP (zeige TMPRSS5 Antikörper)-Hand2 signaling.

3. Results demonstrate a change in Hand2 target genes during maturation of sympathetic neurons. Whereas Hand2 controls genes regulating noradrenergic differentiation during development, Hand2 seems to be involved in the regulation of genes controlling neurotransmission in adult sympathetic neurons.

4. Surviving Hand1 (zeige HAND1 Antikörper);Hand2 mutants display diminished cardiac function that is rescued by concurrent ablation of Hand-null cardiomyocytes. Collectively, we conclude that, within a mixed cardiomyocyte population, removal of defective myocardium and replacement with healthy endogenous cardiomyocytes may provide an effective strategy for cardiac repair.

5. This study showed that Gja1 (zeige GJA1 Antikörper) may act downstream of cAMP-PKA signal to mediate the effects of Acvr1 (zeige ACRV1 Antikörper) on the differentiation of uterine stromal cells through targeting Hand2.

6. transcription of a Hand2-associated long non-coding RNA, which we named upperhand (Uph), is required to maintain the super-enhancer signature and elongation of RNA polymerase II (zeige 0 Antikörper) through the Hand2 enhancer locus

7. endocardial Hand2 is an integral downstream component of a Notch (zeige NOTCH1 Antikörper) endocardium-to-myocardium signaling pathway and a direct transcriptional regulator of Neuregulin1.

8. analysis uncovers the transcriptional circuits that function in establishing distinct mesenchymal compartments downstream of HAND2 and upstream of SHH (zeige SHH Antikörper) signaling

9. Suggest that prenatal alcohol exposure causes the over-expression of DHAND and EHAND (zeige HAND1 Antikörper) by increasing H3K14ac in the fetal heart.

10. Hand2 loss-of-function dramatically reduces expression of Dopamine Beta Hydroxylase (Dbh (zeige DBH Antikörper)), a gene encoding a crucial catecholaminergic biosynthetic enzyme

Zebrafish Heart and Neural Crest Derivatives Expressed 2 (HAND2) Interaktionspartner

1. hand2 and the co-expressed zinc-finger transcription factor osr1 (zeige OSR1 Antikörper) have functionally antagonistic influences on kidney development. Together, our data suggest that hand2 functions in opposition to osr1 (zeige OSR1 Antikörper) to balance the formation of kidney and vein progenitors by regulating cell fate decisions at the lateral boundary of the Iintermediate mesoderm

2. hand2 can drive cardiomyocyte production in multiple contexts and through multiple mechanisms

3. These findings point to complexity of regulation by edn1 and hand2 at the earliest stages of pharyngeal arch development, in which control of growth and morphogenesis can be genetically separated.

4. Data indicate that mouse and zebrafish hand2 enhancers both drive transgene expression in the pharyngeal arches.

5. reduction of fn1 (zeige FN1 Antikörper) function enables rescue of cardiac fusion in hand2 mutants

6. the expression and function of hand2 and dlx3b/4b/5a genes specify major patterning domains along the dorsoventral axis of zebrafish pharyngeal arches

7. Our study reveals an unexpected role for Hand2, a key regulator of cell specification and differentiation, in modulating ECM (zeige MMRN1 Antikörper) remodeling during organogenesis

8. Hand2-endothelin 1 (zeige EDN1 Antikörper) effector, patterns ventral pharyngeal cartilage

9. Hand2 is uniquely required for myocardial polarization.

10. These results demonstrate in vivo an essential and selective function of hand2 for the noradrenergic differentiation of sympathetic neurons, and implicates tfap2a (zeige TFAP2A Antikörper) and gata2 as downstream effectors.