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Topoisomerase II alpha Produkte

(Topoisomerase (DNA) II alpha 170kDa (TOP2A))
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul 2010].

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Ausgewählte Topoisomerase II alpha Kategorien

Topoisomerase II alpha Antikörper

High quality antibodies with extensive validation data.

Topoisomerase II alpha ELISA Kits

Reliable ELISA kits for a wide range of species.

Topoisomerase II alpha Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene Topoisomerase II alpha Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Mouse, Rat
Applikation IHC, IF
Validierungen
  • (12)
Kat. Nr. ABIN7075937
Menge 100 μL
Datenblatt Datenblatt
Reaktivität Human, Rat
Applikation WB, ELISA, FACS, ICC
Validierungen
  • (7)
Kat. Nr. ABIN7193564
Menge 0.1 mg
Datenblatt Datenblatt
Reaktivität Human, Mouse
Applikation WB, IHC, IF, StM
Validierungen
  • (7)
Kat. Nr. ABIN6940773
Menge 100 μg
Datenblatt Datenblatt

Empfohlene Topoisomerase II alpha ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6970754
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Human, Mouse, Rat
Analytical Method Qualitative Cell ELISA
Validierungen
Kat. Nr. ABIN1380860
Menge 2 x 96 tests
Datenblatt Datenblatt
Reaktivität Human
Analytical Method Qualitative Cell ELISA
Validierungen
Kat. Nr. ABIN1380808
Menge 2 x 96 tests
Datenblatt Datenblatt

Empfohlene Topoisomerase II alpha Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN1323347
Menge 10 μg
Datenblatt Datenblatt
Reaktivität Human
Source Insect Cells
Validierungen
  • (1)
Kat. Nr. ABIN3095949
Menge 1 mg
Datenblatt Datenblatt
Reaktivität Mouse
Source Insect Cells
Validierungen
  • (1)
Kat. Nr. ABIN3134769
Menge 1 mg
Datenblatt Datenblatt

Neueste Publikationen zu unseren Topoisomerase II alpha Produkten

Jiang, Mohan, Endo, Shen, Wu: "Type IIB DNA topoisomerase is downregulated by trastuzumab and doxorubicin to synergize cardiotoxicity." in: Oncotarget, Vol. 9, Issue 5, pp. 6095-6108, (2018) (PubMed).

Poonperm, Takata, Hamano, Matsuda, Uchiyama, Hiraoka, Fukui: "Chromosome Scaffold is a Double-Stranded Assembly of Scaffold Proteins." in: Scientific reports, Vol. 5, pp. 11916, (2015) (PubMed).

Lindén, Segersten, Runeson, Wester, Busch, Pettersson, Lind, Malmström: "Tumour expression of bladder cancer-associated urinary proteins." in: BJU international, Vol. 112, Issue 3, pp. 407-15, (2013) (PubMed).

Andersson, Konrad, Ashok, Pontén, Hober, Asplund: "Antibodies biotinylated using a synthetic Z-domain from protein A provide stringent in situ protein detection." in: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 61, Issue 11, pp. 773-84, (2013) (PubMed).

Mondal, Parvin: "DNA topoisomerase IIalpha is required for RNA polymerase II transcription on chromatin templates." in: Nature, Vol. 413, Issue 6854, pp. 435-8, (2001) (PubMed).

Synonyme und alternative Namen zu Topoisomerase II alpha

DNA topoisomerase II alpha (TOP2A), DNA topoisomerase II, alpha isozyme (Bm1_08705), topoisomerase (DNA) II alpha (Top2a), DNA topoisomerase II alpha (Top2a), topoisomerase (DNA) II alpha (TOP2A), Zincin-like metalloproteases family protein (AT5G10540), DNA topoisomerase II alpha (top2a), F12B17.110, F12B17_110, fc08c07, thimet metalloendopeptidase 2, Top-2, TOP-2, TOP2, TOP2A, TP2A, wu:fc08c07

Bezeichner auf Proteinebene für Topoisomerase II alpha

  • DNA gyrase
  • DNA topoisomerase (ATP-hydrolyzing)
  • DNA topoisomerase 2-alpha
  • DNA topoisomerase II, 170 kD
  • DNA topoisomerase II, alpha isozyme
  • DNA Topoisomerase II alpha
  • topoisomerase (DNA) 2 alpha
  • DNA topoisomeraseII_alpha
  • topoisomerase (DNA) II alpha
  • Thimet metalloendopeptidase 2
  • Zincin-like metalloproteases family protein 2
  • topoisomerase 2
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