(Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4))
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008].
Aktuelle Publikationen für unsere TNFRSF4 Proteine
Upadhyaya, Lahdenranta, Hurov, Battula, Dods, Haines, Kleyman, Kristensson, Kublin, Lani, Ma, Mudd, Repash, Van Rietschoten, Stephen, You, Harrison, Chen, McDonnell, Brandish, Keen: "Anticancer immunity induced by a synthetic tumor-targeted CD137 agonist." in: Journal for immunotherapy of cancer, Vol. 9, Issue 1, (2021) (PubMed).
Simons, Lim, Carter, Wagner, Wayham, Adler, Johnson: "Affinity maturation of antibodies by combinatorial codon mutagenesis versus error-prone PCR." in: mAbs, Vol. 12, Issue 1, pp. 1803646, (2020) (PubMed).
Fromm, de Silva, Johannes, Patel, Hornblower, Schreiber: "Agonist redirected checkpoint, PD1-Fc-OX40L, for cancer immunotherapy." in: Journal for immunotherapy of cancer, Vol. 6, Issue 1, pp. 149, (2018) (PubMed).