anti-TLR5 (TLR5) Antikörper

Human Toll-Like Receptor 5 (TLR5) Interaktionspartner

1. results suggest that Hsp90 (zeige HSP90 Antikörper) inhibitors suppress TLR5 surface expression and activation of NF-kappaB (zeige NFKB1 Antikörper) in THP-1 (zeige GLI2 Antikörper) cells in response to TLR5 ligand, and these inhibitory effects may be associated with the possible mechanisms by which Hsp90 (zeige HSP90 Antikörper) inhibitors suppress myeloid leukemia (zeige BCL11A Antikörper).

2. this study signifies that TLR5 adaptor molecules are necessary for the proper production of cytokines, chemokines and pro-labour mediators after TLR ligation

3. the newly found long TLR5 transcripts may be involved in the negative regulation of TLR5 expression and function.

4. It was observed that the TLR5 polymorphisms rs5744168, rs2072493, and rs5744174 are less frequent in Indian Tamils, suggesting that the TLR5 gene remains conserved, which may be due to the genetic selection pressure to withstand prevailing endemic infectious diseases. We observed that these polymorphisms also failed to confer significant risk to develop chronic H. pylori infections and its associated clinical phenotypes

5. we identified significant interactions between TLR5 rs1640827, rs17163737 and Helicobacter pylori infection. This results provide valuable insights into the TLR5 and Helicobacter pylori infection involved in gastric carcinogenesis, and this may have important implications in personalized prevention of GC.

6. TLR 5, 7, and 9 expression patterns differed between HPV-positive and -negative oropharyngeal squamous cell carcinoma patients. In HPV-positive tumors the expression of TLR 5 and 7 correlated with tumor recurrence.

7. These results suggest that HMGB1 (zeige HMGB1 Antikörper)-modulated TLR5 signaling is responsible for pain hypersensitivity.

8. data show that TLR-5 and TLR-9 (zeige TLR9 Antikörper) are susceptible genes to lupus nephritis (LN) and that their expression is dysregulated in LN patients' kidneys, supporting a role of these mediators in the pathogenesis of LN.

9. These results indicate that in Chinese genetic variation of TLR5 may be not a determinant of susceptibility to hepatitis B virus-related diseases but may play a role in development of hepatitis B virus-related severe liver diseases.

10. Distinctive Recognition of Flagellin (zeige FliC Antikörper) by Human and Mouse Toll-Like Receptor 5

Mouse (Murine) Toll-Like Receptor 5 (TLR5) Interaktionspartner

1. hematopoietic TLR5 deficiency inhibits atherosclerotic lesion formation by attenuated macrophage accumulation and defective T-cell responsiveness.

2. Denatured flagellin (zeige FliC Antikörper) suppressed the production of the pro-inflammatory cytokines induced by intact flagellin (zeige FliC Antikörper) or Pseudomonas aeruginosa both in vitro and in vivo, probably by blocking TLR5.

3. Data show that Toll-like receptor 5 (TLR5) plays a role in radiation-induced apoptosis, and CBLB502 pre-treatment could reduce the apoptosis.

4. These results suggest that HMGB1 (zeige HMGB1 Antikörper)-modulated TLR5 signaling is responsible for pain hypersensitivity.

5. data directly demonstrate that nasal epithelial GM-CSF (zeige CSF2 Antikörper) contributes to TLR5-mediated modulation of airway DCs and a subsequent IgA (zeige IgA Antikörper) response.

6. Distinctive Recognition of Flagellin (zeige FliC Antikörper) by Human and Mouse Toll-Like Receptor 5

7. The activation of NLRC4 (zeige NLRC4 Antikörper) by flagellin (zeige FliC Antikörper) downregulated the flagellin (zeige FliC Antikörper)-induced and TLR5-mediated immune responses against flagellin (zeige FliC Antikörper).

8. TLR5 but not NLRC4 (zeige NLRC4 Antikörper) is required for S. pneumoniae FliC (zeige FliC Antikörper)-induced protection.

9. This resulted in Sp1 displacement from the promoter and binding of Sp3 to it, leading to p300 recruitment and histone acetylation, activating transcription. This is the first study addressing the mechanisms of physiological TLR5 expression in the intestine. Additionally, a novel insight is gained into Sp1/Sp3-mediated gene regulation that may apply to other genes

10. TLR5 mediates CD172a (zeige SIRPA Antikörper)(+) intestinal lamina propria dendritic cell induction of Th17 cells.

Cow (Bovine) Toll-Like Receptor 5 (TLR5) Interaktionspartner

1. Both HEK293 (human origin) and embryonic bovine lung cells transfected with bTLR5 responded to addition of H7 flagellin (zeige FliC Antikörper). Responses were significantly reduced when mutations were introduced into the TLR5-binding regions of H7 flagellin (zeige FliC Antikörper).

Pig (Porcine) Toll-Like Receptor 5 (TLR5) Interaktionspartner

1. This study identified variations in the promoter that resulted in changes in TLR5 gene expression.

2. TLR5 takes part in the airway mucosal defense systems as a unique endogenous potentiator of airway serous secretions.

3. The results indicated that TLR5 SNPs were associated with the transcript abundance of cytokines.

Goat Toll-Like Receptor 5 (TLR5) Interaktionspartner

1. Although being highly conserved among the ruminants, comparatively high variations in goat TLR5 might give an opportunity to host for recognizing the wider spectrum of pathogens.

Zebrafish Toll-Like Receptor 5 (TLR5) Interaktionspartner

1. Targeted exchange of drTLR5b and drTLR5a regions revealed that TLR5 activation needs a heterodimeric configuration of the receptor ectodomain and cytoplasmic domain, consistent with ligand-induced changes in receptor conformation

2. Our studies show that Pam3CSK4 and flagellin (zeige FliC Antikörper) can stimulate the Tlr2 and Tlr5 signaling pathways leading to common and specific responses in the zebrafish embryo system.

3. Data suggest that the structure-based modeling study on paFliC, the paFliC-TLR5 complex, and the paFliC filament could contribute to the improvement of vaccine design to control P. aeruginosa infection.

4. the structural basis and mechanistic implications of TLR5-flagellin (zeige FliC Antikörper) recognition