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Human Polyclonal TLR10 Primary Antibody für WB - ABIN550247
Takeda, Kaisho, Akira: Toll-like receptors. in Annual review of immunology 2003
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Polyclonal TLR10 Primary Antibody für WB - ABIN540263
Chuang, Ulevitch: Identification of hTLR10: a novel human Toll-like receptor preferentially expressed in immune cells. in Biochimica et biophysica acta 2001
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Human Polyclonal TLR10 Primary Antibody für ELISA, WB - ABIN1003318
Janeway, Medzhitov: Innate immune recognition. in Annual review of immunology 2002
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Human Polyclonal TLR10 Primary Antibody für IHC (p), WB - ABIN259853
Mulla, Myrtolli, Tadesse, Stanwood, Gariepy, Guller, Norwitz, Abrahams: Cutting-edge report: TLR10 plays a role in mediating bacterial peptidoglycan-induced trophoblast apoptosis. in American journal of reproductive immunology (New York, N.Y. : 1989) 2013
phylogenetic analysis of the cytoplasmic regions of TLR genes suggested that the signal transduction pathway of TLR10 was different from those of TLR1 (zeige TLR1 Antikörper) and TLR6 (zeige TLR6 Antikörper)
Our results indicate that the presence of TLR10 rs10004195, A/T heterozygous, and T/T homozygous genotypes is associated with type 1, 2, and 3 whereas that of the A/A homozygous genotype is associated with type 4 and 5 of gastric mucosal patterns. This suggests that the A/A homozygous genotype contributes to severe inflammation in H. pylori-associated gastritis in Thai patients.
data show increased TLR10 gene/protein expression in the adipose tissue in obesity/type-2 diabetes (T2D) which relates directly with BMI; data also show that ROS (zeige ROS1 Antikörper)-mediated oxidative stress could induce expression of TLR10 in monocytic cells through the mechanism that involves NF-kappaB (zeige NFKB1 Antikörper) and MAPK (zeige MAPK1 Antikörper) signaling pathways and the ER stress response
A TLR10 allelic variant, I473T, has impaired NFkB inhibitory activity and is highly associated with disease severity and low response to infliximab in patients with rheumatoid arthritis
The data demonstrate that TLR10 is a novel regulator of innate immune responses and of the differentiation of primary human monocytes into effective dendritic cells.
these results demonstrate that TLR10 functions as a broad negative regulator of TLR signaling
Our results demonstrate that TLR10 has a functional role within the B cell lineage that is distinct from that of other TLR family members
Study concludes that genetic variation in the TLR10-TLR1-TLR6 (zeige TLR6 Antikörper) gene cluster mediates responsiveness to organic dust, but indicates different signaling pathways for IL-6 (zeige IL6 Antikörper) and TNF-alpha (zeige TNF Antikörper). These studies provide new insight into the role of the TLR10-TLR1-TLR6 (zeige TLR6 Antikörper) gene cluster and the innate immune response to organic dust.
Our results suggest that TLR10 is involved in the recognition of FSL-1 (zeige FSTL1 Antikörper), LPS (zeige IRF6 Antikörper), and flagellin (zeige FliC Antikörper) and TLR-ligand-induced expression of TNF-alpha (zeige TNF Antikörper) does not depend on TLR10.
Data indicate that polymorphisms in toll like receptor 10 (TLR10) are not associated with chronic Q fever.
Study annotated variants at 4p14 as expression quantitative trait loci (eQTL (zeige EQTN Antikörper)) associated with TLR6 (zeige TLR6 Antikörper)/10 and FAM114A1 (zeige FAM114A1 Antikörper); findings suggest that 4p14 polymorphisms are linked to host immune response to H. pylori infection but not to its acquisition.
The expression analysis showed similar expression profiles for TLR1 (zeige TLR1 Antikörper) and TLR6 (zeige TLR6 Antikörper), which indicate a co-regulation of these two genes, TLR10 had a different expression profile, pointing toward a stronger functional diversification compared to TLR1 (zeige TLR1 Antikörper) and TLR6 (zeige TLR6 Antikörper).
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is most highly expressed in lymphoid tissues such as spleen, lymph node, thymus, and tonsil. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene.
toll-like receptor 10
, toll-like receptor 10-like