Kaninchen ''B'' (1-2 Lbs.) Complement (Lyophilized) With Diluent
Kurzübersicht für Kaninchen ''B'' (1-2 Lbs.) Complement (Lyophilized) With Diluent (ABIN925152)
Wirt
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Hersteller Produkt- Nr.
- c203-0005
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Hersteller
- Rockland
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Spezifität
- The complement system consists of a number of small proteins found in the blood, generally synthesized by the liver, and normally circulating as inactive precursors (pro-proteins). When stimulated by one of several triggers, proteases in the system cleave specific proteins to release cytokines and initiate an amplifying cascade of further cleavages. The end-result of this activation cascade is massive amplification of the response and activation of the cell-killing membrane attack complex. Over 25 proteins and protein fragments make up the complement system, including serum proteins, serosal proteins, and cell membrane receptors. They account for about 5% of the globulin fraction of blood serum.
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Produktmerkmale
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Strain: Rabbit - New Zealand White
Sex: Mixed -
Aufreinigung
- Complement
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Sterilität
- Non-sterile
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Bestandteile
- with Diluent
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Rat Tail
Wirt: Ratte
Guinea Pig Spinal CordWirt: Meerschweinchen Normal Spinal Cord
Sheep Red Blood Cells (10% Washed Pooled Cells)H Wirt: Schaf Normal Red Blood Cells
Mouse BrainIEM, IHC, WB Wirt: Maus Normal Brain
Chicken Red Blood Cells (10% Washed Pooled Cells)H Wirt: Huhn Normal Red Blood Cells
Hamster Complement (Lyophilized) With DiluentWirt: Hamster Normal Complement
Guinea Pig Complement (Lyophilized) With DiluentWirt: Meerschweinchen Normal Complement
Rabbit Blood (In Sodium Citrate)H Wirt: Kaninchen Normal Blood
Sheep Red Blood Cells (100% Washed Pooled Cells)H Wirt: Schaf Normal Red Blood Cells
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Applikationshinweise
- pH: normal Immunoelectrophoresis: normal Hemoglobin: normal IgG Concentration: normal Immunoelectrophoresis: normal
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Kommentare
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The rabbit complement system helps or “complements” the ability of antibodies and phagocytic cells to clear pathogens from an organism. Complement is part of the innate immune system that is not adaptable and does not change over the course of an individual's lifetime. Complement can be recruited and brought into action by the adaptive immune system. The following are basic functions of complement: 1. Opsonisation - enhancing phagocytosis of antigens 2. Chemotaxis - attracting macrophages and neutrophils 3. Cell Lysis - rupturing membranes of foreign cells 4. Clumping of antigen-bearing agents
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Frozen
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Rekonstitution
- Reconstitution Buffer: Restore with deionized water (or equivalent), Reconstitution Volume: 5.0 mL
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Konzentration
- 85 mg/mL
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Handhabung
- Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. COMPLEMENT IS A TEMPERATURE SENSITIVE PRODUCT. IMPROPER STORAGE WILL INACTIVATE COMPLEMENT ACTIVITY.
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Lagerung
- 4 °C
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Haltbarkeit
- 12 months
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Hintergrund
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The rabbit complement system helps or “complements” the ability of antibodies and phagocytic cells to clear pathogens from an organism. Complement is part of the innate immune system that is not adaptable and does not change over the course of an individual's lifetime. Complement can be recruited and brought into action by the adaptive immune system. The following are basic functions of complement: 1. Opsonisation - enhancing phagocytosis of antigens 2. Chemotaxis - attracting macrophages and neutrophils 3. Cell Lysis - rupturing membranes of foreign cells 4. Clumping of antigen-bearing agents
Synonyms: Complement system, tissue macrophages, blood monocytes, protease C3-convertase, mannose-binding lectin pathway, C3, C3a, C3b, C5a, C5b, C6, C7, C8, and polymeric C9, cascade cleavage and activation events, recruit inflammatory cells, anaphylatoxin.
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