anti-TERT (TERT) Antikörper

Human Telomerase Reverse Transcriptase (TERT) Interaktionspartner

1. Although hsa_circ_0020397 did not influence miR (zeige MLXIP Antikörper)-138 expression per se, has_circ_0020397 did inhibit miR (zeige MLXIP Antikörper)-138 activity, as examined via the expression of miR (zeige MLXIP Antikörper)-138 targets telomerase reverse transcriptase (TERT) and programmed death-ligand 1 (PD-L1 (zeige CD274 Antikörper)).

2. The hTERT mRNA levels are frequently upregulated in peripheral blood and CTCs in the patients with nasopharyngeal carcinoma (NPC (zeige NPC1 Antikörper)) and also the overexpression of hTERT mRNA correlated with clinicopathological parameters of NPC (zeige NPC1 Antikörper).

3. results indicate that KMT2A (zeige MLL Antikörper) promotes melanoma growth by activating the hTERT signaling, suggesting that the KMT2A (zeige MLL Antikörper)/hTERT signaling pathway may be a potential therapeutic target for melanoma.

4. RAS-ERK (zeige EPHB2 Antikörper) signaling in BRAF (zeige BRAF Antikörper) mutant melanomas is critical for regulating active chromatin state and recruitment of RNA polymerase II (zeige 0 Antikörper) at mutant TERT promoters. Our study provides evidence that the mutant TERT promoter is a key substrate downstream of the RAS-ERK (zeige EPHB2 Antikörper) pathway.

5. The TERT(C228T) mutation status was an independent prognostic factor for recurrence-free survival (hazard ratio = 3.08 [confidence interval 1.042-9.079]; p = 0.042) in patients with papillary thyroid carcinoma in multivariate analysis

6. there is an association between telomere length, telomerase activity, hTERT expression and alpha1-antitrypsin deficiency phenotypes

7. These data suggest that TERT promoter mutations contribute to tumorigenesis by promoting immortalization and genomic instability in two phases.

8. Our data suggest that Kras mutations increase telomerase activity and telomere length by activating the RAS/MEK (zeige MAP2K1 Antikörper) pathway, which contributes to an aggressive phenotype of NSCLC.

9. mutations in TERT promoter disclose the significance of both nuclear and cytoplasmic TERT in HCC (zeige FAM126A Antikörper). Cytoplasmic TERT should also be considered when determining prognosis and treatment of HCCs (zeige HCCS Antikörper).

10. expression of TERT does not differ in neoplastic and nonneoplastic pituitary tissues

Caenorhabditis elegans (C. elegans) Telomerase Reverse Transcriptase (TERT) Interaktionspartner

1. The results establish that null mutation in trt-1 improves survival and attenuates damage to the DAergic system.

2. trt-1 is the Caenorhabditis elegans catalytic subunit of telomerase

Cow (Bovine) Telomerase Reverse Transcriptase (TERT) Interaktionspartner

Zebrafish Telomerase Reverse Transcriptase (TERT) Interaktionspartner

1. The expression of telomerase activity and TERT in retina implies that telomerase has functions other than the elongation of telomere. These findings could provide new insights on telomerase function in the nervous system.

2. methylation status of the genes of telomerase reverse transcriptase (tert) and telomerase RNA (terc) was determined in brain tissues; study found that, regardless of the age of fish, the regulatory region of the tert gene was completely methylated, whereas the coding region remained unmethylated

3. Telomerase-deficient zebrafish show p53 (zeige TP53 Antikörper)-dependent premature aging and reduced lifespan in the first generation.

4. These results suggest that TERT non-canonically functions in hematopoietic cell differentiation and survival in vertebrates, independently of its role in telomere homeostasis.

Arabidopsis thaliana Telomerase Reverse Transcriptase (TERT) Interaktionspartner

1. Telomere shortening is more rapid in fas (zeige FASN Antikörper) tert double mutants than in fas1 (zeige FAS Antikörper), fas2 or tert single mutant plants.

2. Silencing of the AtTERT gene is associated with increased H3K27me3 loading and maintenance of its euchromatic environment.

3. study reports the physical interaction of an Arabidopsis POT1 (zeige POT1 Antikörper) protein, POT1A (zeige POT1 Antikörper) (At5g05210), with an N-terminal peptide of the catalytic subunit of the telomerase TERT encoded by a 5' mRNA splicing variant

4. AtTERT, the telomerase catalytic subunit, accumulates in the plant nucleolus, and AtNAP57 (zeige DKC1 Antikörper) associates with active telomerase RNP (zeige RNPC3 Antikörper) particles in an RNA-dependent manner.

5. Attert (-/-) mutant plants were propagated from seeds coming either from the lower-most or the upper-most siliques (L- and U-plants) and the length of their telomeres were followed over several generations.

Medaka Telomerase Reverse Transcriptase (TERT) Interaktionspartner

1. Tert was cloned from testis. It is expresed in embryo and adult, mostly in gonad and brain. 2 splice variants and an antisense transcript were identified.

2. The Japanese medaka is a new vertebrate model for studying tert biology.

Mouse (Murine) Telomerase Reverse Transcriptase (TERT) Interaktionspartner

1. Reactivation of Tert in the hippocampus was sufficient to normalize the depressive but not the aggressive behaviors of Tert(-/-) mice. Conversely, re-expression of Tert in the medial prefrontal cortex (mPFC) reversed the aggressive but not the depressive behavior of Tert(-/-) mice.

2. Nrf2 (zeige NFE2L2 Antikörper)-driven TERT regulates pentose phosphate pathway in glioblastoma.

3. TERT has a role in neointima formation through epigenetic regulation of proliferative E2F1 (zeige E2F1 Antikörper) target gene expression in smooth muscle cells.

4. these findings support a model in which gain of TERT function modulates mTORC1 activity and induces autophagy.

5. Regarding extratelomeric activities, our results showed a decrease of 64, 38 and 25% in the transcription of c-Myc (zeige MYC Antikörper), Cyc (zeige CYCS Antikörper)-D1 and TERT, respectively (p<0.05) after AZT treatment. Furthermore, we found an effect on cell migration, reaching an inhibition of 48% (p<0.05) and a significant passage-dependent increase on cell doubling time during treatment

6. Results suggest that in mature Purkinje neurons, TERT is present both in the nucleus and in mitochondria, where it may participate in adaptive responses of the neurons to excitotoxic and radiation stress

7. Wnt10a (zeige WNT10A Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) signaling pathway is able to exacerbate keloid cell proliferation and inhibit the apoptosis of keloid cells through its interaction with TERT.

8. This study reports the characterisation of two novel mouse TERT splice variants, Ins (zeige INS Antikörper)-i1[1-102] (Insi1 for short) and Del-e12 (zeige ELSPBP1 Antikörper)[1-40] (Dele12 for short) that have not been previously described. Insi1 represents an in-frame insertion of nucleotides 1-102 from intron 1, encoding a 34 amino acid insertion at amino acid 73.

9. TERT may promote gastric cancer metastasis through the TERT-miR (zeige MLXIP Antikörper)-29a-ITGB1 (zeige ITGB1 Antikörper) regulatory pathway.

10. TERT switches macrophages towards M1 phenotype by regulating NF-kappaB (zeige NFKB1 Antikörper) signaling, but has limited effect on M2 macrophages polarization in vitro.

Xenopus laevis Telomerase Reverse Transcriptase (TERT) Interaktionspartner

1. TERT serves an essential role in formation of the anterior-posterior axis in Xenopus laevis embryos; role for telomerase as a transcriptional modulator of the Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) signalling pathway